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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 211 - 219 (9page)
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Objective. This study assessed the efficacy and safety of secukinumab and adalimumab in patients with active ankylosing spondylitis (AS). Methods. A Bayesian network meta-analysis was performed with direct and indirect data collected from randomized controlled trials (RCTs) of efficacy and safety of secukinumab 75 mg, 150 mg and adalimumab 40 mg in patients with active AS. Results. Five RCTs (1,483 patients) met the inclusion criteria. The Assessment in Spondyloarthritis International Society response criteria of ≥20% (ASAS20) response rate was significantly higher in the adalimumab 40 mg (Odds ratio [OR], 4.26; 95% credible interval [CrI], 2.09∼8.08), secukinumab 150 mg (OR, 3.35; 95% CrI, 1.73∼6.56), and 75 mg dose (OR, 2.44; 95% CrI, 1.06∼5.05) than with placebo. The ranking probability based on the surface under the cumulative ranking curve (SUCRA) indicated that adalimumab 40 mg had the highest probability of being the best treatment for achieving an ASAS20 response (SUCRA=0.8753), followed by secukinumab 150 mg (SUCRA=0.7051), secukinumab 75 mg (SUCRA=0.4113), and placebo (SUCRA=0.0083). The ASAS40 response rate distribution pattern was similar to the ASAS20 response rate. However, the number of serious adverse events did not differ significantly among the treatment options. Conclusion. Secukinumab and adalimumab were effective for the treatment of active AS without causing a significant risk of serious adverse events.
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참고문헌 (27)
참고문헌 신청
Brown MA / 2002 / Genetics of ankylosing spondylitis / Clin Exp Rheumatol 20(6 Suppl 28):S43~S49
박로빈 / 2016 / Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets / 대한류마티스학회지 23(6):363~372
Braun J / 2011 / 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis / Ann Rheum Dis 70:896~904
Braun J / 1995 / Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis / Arthritis Rheum 38:499~505
Baeten D / 2013 / Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial / Lancet 382:1705~1713
박로빈 / 2016 / Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets / 대한류마티스학회지 23(6):363~372
Braun J / 2011 / 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis / Ann Rheum Dis 70:896~904
Braun J / 1995 / Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis / Arthritis Rheum 38:499~505
Baeten D / 2013 / Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial / Lancet 382:1705~1713
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