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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Gout is one of the most common forms of acute inflammatory arthritis caused by long-standing hyperuricemia. Various clinical and epidemiological studies have demonstrated that uric acid, which is strongly associated with the pathogenesis of gout, is closely related with increased cardiovascular (CV) risk. Thus, properly controlling uric acid levels within its physiological level using urate-lowering therapy has been hypothesized to improve CV outcomes. Recently, however, on the basis of the results of the largest prospective, the double-blind, randomized controlled trial, entitled “the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES),” has aroused the possibility of increased CV-related and all-cause mortality in patients receiving febuxostat. Largely on the basis of this unpredicted result, the US and Korea Food and Drug Administration issued a public safety alert concerning the high risk of CV death with the use of febuxostat in February 2019. This unexpected announcement left many rheumatologists confused when they decide the first-line urate-lowering drug in Korea. In this review, we searched for previous studies on uric acid and increased risk of CV disease. In addition, we will introduce various interpretations of the results of the CARES trial and discuss the best choice of urate-lowering therapy for Korean.
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참고문헌 (66)
참고문헌 신청
Dalbeth N / 2016 / Gout / Lancet 388:2039~2052
Richette P / 2020 / 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout / Ann Rheum Dis 79:31~38
Elfishawi MM / 2018 / The rising incidence of gout and the increasing burden of comorbidities : a population-based study over 20 years / J Rheumatol 45:574~579
Kim JW / 2017 / Prevalence and incidence of gout in Korea : data from the National Health Claims Database 2007-2015 / Rheumatol Int 37:1499~1506
Kuo CF / 2015 / Rising burden of gout in the UK but continuing suboptimal management : a nationwide population study / Ann Rheum Dis 74:661~667
Richette P / 2020 / 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout / Ann Rheum Dis 79:31~38
Elfishawi MM / 2018 / The rising incidence of gout and the increasing burden of comorbidities : a population-based study over 20 years / J Rheumatol 45:574~579
Kim JW / 2017 / Prevalence and incidence of gout in Korea : data from the National Health Claims Database 2007-2015 / Rheumatol Int 37:1499~1506
Kuo CF / 2015 / Rising burden of gout in the UK but continuing suboptimal management : a nationwide population study / Ann Rheum Dis 74:661~667
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