지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.2
- 발행연도
- 2015.1
- 수록면
- 190 - 194 (5page)
이용수
초록· 키워드
오류제보하기
Eosinophils have been reported to modulate T cell responses. Previously, we reported that high-mobility group box 1 protein (HMGB1) played a keyrole in the pathogenesis of asthma. This study was conducted to test our hypothesis that eosinophils could modulate T cell responses via HMGB1 inthe pathogenesis of asthma characterized by eosinophilic airway inflammation. We performed in vitro experiments using eosinophils, dendritic cells(DCs), and CD4+ T cells obtained from a murine model of asthma. The supernatant of the eosinophil culture was found to significantly increase thelevels of interleukin (IL)-4 and IL-5 in the supernatant of CD4+ T cells co-cultured with DCs. HMGB1 levels increased in the supernatant of the eosinophilculture stimulated with IL-5. Anti-HMGB1 antibodies significantly attenuated increases of IL-4 and IL-5 levels in the supernatant of CD4+ T cellsco-cultured with DCs that were induced by the supernatant of the eosinophil culture. In addition, anti-HMGB1 antibodies significantly attenuatedthe expressions of activation markers (CD44 and CD69) on CD4+ T cells. Our data suggest that eosinophils modulate CD4+ T cell responses viaHMGB1 in the pathogenesis of asthma.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Walsh ER / 2010 / Eosinophils and allergic airway disease: there is more to the story / Trends Immunol 31:39~44
Jacobsen EA / 2008 / Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells / J Exp Med 205:699~710
Walsh ER / 2008 / Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma / J Exp Med 205:1285~1292
Lotze MT / 2005 / High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal / Nat Rev Immunol 5:331~342
Shim EJ / 2012 / The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma / Clin Exp Allergy 42:958~965
Jacobsen EA / 2008 / Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells / J Exp Med 205:699~710
Walsh ER / 2008 / Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma / J Exp Med 205:1285~1292
Lotze MT / 2005 / High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal / Nat Rev Immunol 5:331~342
Shim EJ / 2012 / The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma / Clin Exp Allergy 42:958~965
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death
Clinical and Experimental Otorhinolaryngology
2015 .01
-
Regulatory Eosinophils in Inflammation and Metabolic Disorders
Immune Network
2017 .02
-
Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort
Journal of Korean Medical Science
2022 .02
-
소아 천식 및 호산구성기관지염에서 유도객담 호산구분율과 혈청 및 혈액 알레르기 지표와 연관성
Allergy Asthma & Respiratory Diseases
2020 .01
-
The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease
Immune Network
2020 .06
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues
Immune Network
2016 .04
-
Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
Clinical and Experimental Pediatrics
2019 .01
-
Ovalbumin으로 유발된 천식 동물모델에서 GGX의 효과
대한한방내과학회지
2023 .06
-
Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?
Allergy, Asthma & Immunology Research
2019 .01
-
Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
Immune Network
2019 .06
-
杏仁 분획물이 Th2 cytokine 발현과 NC/Nga mouse의아토피 피부염에 미치는 영향
대한한방소아과학회지
2016 .01
-
Low-Dose Mepolizumab Effectiveness in Patients Suffering From Eosinophilic Granulomatosis With Polyangiitis
Allergy, Asthma & Immunology Research
2020 .01
-
T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Cancer Research and Treatment
2020 .01
-
Association of Single Nucleotide Polymorphisms in Interleukin-12 Receptor (IL-12Rβ1 and IL-12Rβ2) with Asthma in a Korean Population
대한의생명과학회지
2020 .12
-
Increased Serum High Mobility Group Box 1 (HMGB1) Concentration and the Altered Expression of HMGB1 and Its Receptor Advanced Glycation Endproducts in Pemphigus
Annals of Dermatology
2017 .01
-
Vascular and immune cell network in the pathogenesis of atherosclerosis
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Eosinophil Extracellular Traps Pave the Way for the Identification of Novel Therapeutics in Severe Asthma
Allergy, Asthma & Immunology Research
2022 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0