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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 67 - 80 (14page)
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초록· 키워드
오류제보하기
Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. We describe pathologic aspects of eosinophils with a role in asthma and in various GI diseases, including eosinophilic GI disorders, inflammatory bowel disease, and radiation-induced enteropathy. Finally, we discuss the beneficial role of eosinophils, which contribute to the resolution of pathogenic conditions and to the modulation of homeostatic biologic responses.
목차
ABSTRACT
INTRODUCTION
BIOLOGICAL CHARACTERISTICS OF EOSINOPHILS
EOSINOPHILS AS PRO-INFLAMMATORY DESTRUCTIVE CELLS IN DISEASE
EOSINOPHILS AS BENEFICIAL REGULATORS IN HOST DEFENSE AND MODULATORS OF TISSUE HOMEOSTASIS
CONCLUSION
REFERENCES
참고문헌 (83)
참고문헌 신청
Jung Y / 2014 / Roles and regulation of gastrointestinal eosinophils in immunity and disease / J Immunol 193:999~1005
정윤재 / 2015 / Comparative Analysis of Dibutyric cAMP and Butyric Acid on the Differentiation of Human Eosinophilic Leukemia EoL-1 Cells / Immune Network 15(6):313~318
Rothenberg ME / 2006 / The eosinophil / Annu Rev Immunol 24:147~174
Rosenberg HF / 2013 / Eosinophils : changing perspectives in health and disease / Nat Rev Immunol 13:9~22
Weller PF / 2017 / Functions of tissue-resident eosinophils / Nat Rev Immunol 17:746~760
정윤재 / 2015 / Comparative Analysis of Dibutyric cAMP and Butyric Acid on the Differentiation of Human Eosinophilic Leukemia EoL-1 Cells / Immune Network 15(6):313~318
Rothenberg ME / 2006 / The eosinophil / Annu Rev Immunol 24:147~174
Rosenberg HF / 2013 / Eosinophils : changing perspectives in health and disease / Nat Rev Immunol 13:9~22
Weller PF / 2017 / Functions of tissue-resident eosinophils / Nat Rev Immunol 17:746~760
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Terminally Differentiating Eosinophils Express Neutrophil Primary Granule Proteins as well as Eosinophil-specific Granule Proteins in a Temporal Manner
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Eosinophils Modulate CD4+ T Cell Responses via High Mobility Group Box-1 in the Pathogenesis of Asthma
Allergy, Asthma & Immunology Research
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Editorial : Is determining nasal eosinophil count and nasal eosinophil peroxidase concentration clinically useful in children with rhinits?
Clinical and Experimental Pediatrics
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Biology and Function of Eosinophils in Chronic Rhinosinusitis With or Without Nasal Polyps
Allergy, Asthma & Immunology Research
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Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat
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2016 .03
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Low-Dose Mepolizumab Effectiveness in Patients Suffering From Eosinophilic Granulomatosis With Polyangiitis
Allergy, Asthma & Immunology Research
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A Rare Case of Eosinophilic Gastroenteritis in a Neonate with Fever
Neonatal medicine
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Quantitative Analysis of Distribution of the Gastrointestinal Tract Eosinophils in Childhood Functional Abdominal Pain Disorders
Journal of Neurogastroenterology and Motility (JNM)
2018 .01
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Eosinophil Extracellular Traps Pave the Way for the Identification of Novel Therapeutics in Severe Asthma
Allergy, Asthma & Immunology Research
2022 .09
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CCR3 Monoclonal Antibody Inhibits Eosinophilic Inflammation and Mucosal Injury in a Mouse Model of Eosinophilic Gastroenteritis
Allergy, Asthma & Immunology Research
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Eosinophils are Required for Immune Responses Induced by Oral Immunization
JOURNAL OF BACTERIOLOGY AND VIROLOGY
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Degranulated Eosinophils Contain More Fine Nerve Fibers in the Duodenal Mucosa of Patients With Functional Dyspepsia
Journal of Neurogastroenterology and Motility (JNM)
2019 .01
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UCI(KEPA) : I410-ECN-0101-2020-517-000894344