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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.11 No.3
- 발행연도
- 2019.1
- 수록면
- 320 - 329 (10page)
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Eosinophils have long been recognized as a central effector cell in the lungs of asthmatic patients. They contribute to airway inflammation and remodeling through releasing several molecules such as cytokines, granule proteins, lipid mediators and extracellular traps/vesicles. Repeated evidence reveals that intense eosinophil infiltration in upper and lower airway mucosae contributes to the pathogenesis of aspirin-exacerbated respiratory disease (AERD). Persistent eosinophilia is found to be associated with type 2 immune responses, cysteinyl leukotriene overproduction and eosinophil-epithelium interactions. This review highlights recent findings about key mechanisms of eosinophil activation in the airway inflammation of AERD. In addition, current biologics (targeting type 2 immune responses) were suggested to control eosinophilic inflammation for AERD patients.
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등록된 정보가 없습니다.
참고문헌 (68)
참고문헌 신청
Lee JH / 2018 / An update on the management of aspirin-exacerbated respiratory disease / Expert Rev Respir Med 12:137~143
Gauvreau GM / 2001 / Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma / Am J Respir Crit Care Med 164:1495~1500
Okano M / 2015 / Association and management of eosinophilic inflammation in upper and lower airways / Allergol Int 64:131~138
Conley DB / 2006 / Superantigens and chronic rhinosinusitis : skewing of T-cell receptor V beta-distributions in polyp-derived CD4+ and CD8+ T cells / Am J Rhinol 20:534~539
Laidlaw TM / 2016 / Aspirin-exacerbated respiratory disease--new prime suspects / N Engl J Med 374:484~488
Gauvreau GM / 2001 / Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma / Am J Respir Crit Care Med 164:1495~1500
Okano M / 2015 / Association and management of eosinophilic inflammation in upper and lower airways / Allergol Int 64:131~138
Conley DB / 2006 / Superantigens and chronic rhinosinusitis : skewing of T-cell receptor V beta-distributions in polyp-derived CD4+ and CD8+ T cells / Am J Rhinol 20:534~539
Laidlaw TM / 2016 / Aspirin-exacerbated respiratory disease--new prime suspects / N Engl J Med 374:484~488
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