지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 386 - 393 (8page)
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초록· 키워드
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Purpose: Few studies address independent prognostic factors after ipsilateral breast tumor recurrence (IBTR) following breastconserving surgery (BCS). Locoregional recurrence is associated with distant metastases and increased mortality rates. Therefore anticipating prognoses after IBTR and evaluating risk factors for overall survival following a second salvage operation are important. We evaluated independent prognostic factors affecting overall survival after a second operation for IBTR. Methods: We retrospectively identified 11,073 patients who underwent breast cancer surgery between November 1995 and December 2011. Locoregional recurrence occurred in 787 patients. Among them, IBTR developed in 165 patients selected for analysis. Excluding eight patients who refused further treatment, we analyzed 157 patients who underwent a second operation (partial mastectomy, 28 [17.8%]; total mastectomy, 129 [82.2%]) for IBTR. Excluding 26 patients with incomplete data, we evaluated the clinicopathological features influencing overall survival at the first and the second operation in the 131 patients who underwent a second operation. Results: The median age of patients at the first operation was 43.6 years (range, 27–69 years). The median duration from the first to the second operation was 45.0 months (range, 2.5–164.6 months). The 5-year overall survival rate after IBTR was 87.1%. In the multivariable analyses, duration from the first to the second operation, histopathology, lymph node status, and adjuvant chemotherapy, radiotherapy, and endocrine therapy at the first operation were independent prognostic factors for overall survival. Positive estrogen receptor status and endocrine therapy at the second operation were also associated with increased overall survival following salvage operations for IBTR. Conclusion: The time interval to IBTR following BCS is related to overall survival after salvage operation for IBTR and it is important to undergo optimal adjuvant treatments according to risk factors after the first operation because those risk factors affect overall survival for IBTR following BCS.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241
Arriagada R / 1996 / Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group / J Clin Oncol 14:1558~1564
Fisher B / 1995 / Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer / N Engl J Med 333:1456~1461
Lichter AS / 1992 / Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast : a randomized trial at the National Cancer Institute / J Clin Oncol 10:976~983
van der Sangen MJ / 2013 / Prognosis following local recurrence after breast conserving treatment in young women with early breast cancer / Eur J Surg Oncol 39:892~898
Arriagada R / 1996 / Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group / J Clin Oncol 14:1558~1564
Fisher B / 1995 / Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer / N Engl J Med 333:1456~1461
Lichter AS / 1992 / Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast : a randomized trial at the National Cancer Institute / J Clin Oncol 10:976~983
van der Sangen MJ / 2013 / Prognosis following local recurrence after breast conserving treatment in young women with early breast cancer / Eur J Surg Oncol 39:892~898
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