Oncologic safety of breast-conserving surgery in breast cancer patients under the age of 35

Incheon Kang; Joo Heung Kim; Seho Park; Ho Hur; Hyung Seok Park; Seung Il Kim; Young Up Cho

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자료유형: 학술저널

저자정보: Incheon Kang (Yonsei University) Joo Heung Kim (Yonsei University) Seho Park (Yonsei University) Ho Hur (National Health Insurance Service Ilsan Hospital) Hyung Seok Park (Yonsei University) Seung Il Kim (Yonsei University) Young Up Cho (Yonsei University)

저널정보: 대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제13권 제1호

발행연도: 2017.6

수록면: 32 - 38 (7page)

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Purpose: Breast-conserving surgery (BCS) shows no difference in survival rates compared with total mastectomy. So, BCS is considered standard breast surgery with modified radical mastectomy. But in patients who received BCS, there is a risk of local recurrence in their long term follow up periods. Especially, BCS of young age is controversial regarding oncologic safety because of local recurrence. In this study, we struggle to confirm the oncologic safety of BCS compared with total mastectomy under the age of 35 in South Korea.
Methods: All patients who underwent surgery for breast cancer were 5,366 at Severance Hospital, Yonsei University Health System, from January 1981 to April 2008. Of them, patients younger than 35 years old were 547. We excluded patients who received chemotherapy before surgery and included only stage 1 and 2 patients who identified through the pathology after surgery. Finally, we got 367 patients; total mastectomy was performed in 245 and BCS, in 122. We compared clinicopathological characteristics and oncologic outcomes between two groups using SPSS program.
Results: In patients received BCS, a local recurrence rate was 7.7% at 5 years and up to 20.3% at 10 years. In patients received total mastectomy, a local recurrence rate was 1.9% over 10 years (P<0.001). However, there was no difference in 5-year and 10-year overall survival rates between two groups (P=0.689). Adjuvant chemotherapy decreased local recurrence rate in BCS patients (P=0.019).
Conclusion: So, we concluded that BCS under the age of 35 has oncologic safety with undergoing chemotherapy.

#Age factors #Breast-conserving surgery #Breast neoplasms #Local neoplasm recurrence #Survival rate

참고문헌 (19)

참고문헌 신청

[학술지(정기간행물)] - Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347 : 1227 ~ 1232

[학술지(정기간행물)] - Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347 : 1233 ~ 1241

[학술지(정기간행물)] - van Dongen JA / 2000 / Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial / J Natl Cancer Inst 92 : 1143 ~ 1150

[학술지(정기간행물)] - Blichert-Toft M / 1992 / Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish Breast Cancer Cooperative Group / J Natl Cancer Inst Monogr : 19 ~ 25

[학술지(정기간행물)] - Vicini FA / 2003 / Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy? / Cancer 97 : 910 ~ 919

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