A comparative study of the clinical characteristics of breast cancer patients less than 35 years old and older patients

Tae Sik Hwang; Ah Rem Jeong; Joung Won Na; Yun Yeong Kim; Joon-Hyop Lee; Yoo Seung Chung; Sang Tae Choi; Jin Mo Kang; Heung Kyu Park; Yong Soon Chun

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저자정보: Tae Sik Hwang (Gil Medical Center) Ah Rem Jeong (Gil Medical Center) Joung Won Na (Gil Medical Center) Yun Yeong Kim (Gil Medical Center) Joon-Hyop Lee (Gil Medical Center) Yoo Seung Chung (Gil Medical Center) Sang Tae Choi (Gil Medical Center) Jin Mo Kang (Gil Medical Center) Heung Kyu Park (가천대학교 길병원) Yong Soon Chun (Gil Medical Center)

저널정보: 대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제14권 제1호

발행연도: 2018.6

수록면: 1 - 7 (7page)

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Purpose: In Korea, the incidence of breast cancer peaks in the fifth decade, which is younger than that observed in the Western world. We conducted this study to compare the clinical characteristics and prognostic factors of breast cancer in women ＜35 and ≥35 years old.
Methods: The medical records of 969 patients treated for breast cancer at the Gil Medical Center from 2008 through 2012 were reviewed. Tumor characteristics, surgical methods, and adjuvant therapies were compared in two groups.
Results: Number of childbirths, family history, the proportion of postmenopausal women were lower among those aged ＜35 years. However, tumor size, number of metastatic lymph nodes, and surgical procedures were similar in two groups. The rate of triple negative status in younger patients was higher than in older patients. Adjuvant chemotherapy was effective in patients positive for hormone receptors and no lymph nodal invasion, and it was effective in patients negative for hormone receptors and lymph nodal invasion in patients aged ＞35 years old. Postoperative radiotherapy was statistically effective in patients aged ＜35 and ≥35 years old that underwent breast-conserving surgery. Pregnancy were significantly associated with survival in younger patients. While lymph node stage, presence of progesterone receptor, and triple negative status were significantly associated with survival on older patients.
Conclusion: The prognostic factors of breast cancer in patients younger than 35 years old were pregnancy. Triple negative status rate was higher in younger patients than in older patients. Adjuvant therapy had similar effects in patients aged ＜35 or ≥35 years old.

#Breast neoplasms #Prognosis #Young adult

참고문헌 (14)

참고문헌 신청

Siegel R / 2014 / Cancer statistics, 2014 / CA Cancer J Clin 64:9~29

정규원 / 2017 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014 / Cancer Research and Treatment 49(2):292~305

Ministry of Health and Welfare / Cancer statistics

Min YK / 2001 / Clinical characteristics and prognosis of young age (35 year old or younger) onset breast cancer / J Korean Surg Soc 60:612~617

Paik NS / 2014 / Current status of breast cancer in Korea / Ewha Med J 37:69~74

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