Comparison of Long-Term Oncological Outcomes in Oncoplastic Breast Surgery and Conventional Breast-Conserving Surgery for Breast Cancer: A Propensity Score-Matched Analysis

오문영; 김유미; 김지호; 천종호; 정지광; 김홍규; 이한별; 한원식

doi:10.4048/jbc.2021.24.e52

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자료유형: 학술저널

저자정보: 오문영 (Department of Surgery Seoul National University College of Medicine Seoul Korea.) 김유미 (Department of Surgery Seoul National University College of Medicine Seoul Korea.CHA Gangnam Medical) 김지호 (Seoul National University College of Medicine Seoul Korea.) 천종호 (Department of Surgery Seoul National University College of Medicine Seoul Korea) 정지광 (Department of Surgery Seoul National University College of Medicine Seoul Korea.) 김홍규 (Department of Surgery Seoul National University College of Medicine Seoul Korea.) 이한별 (Department of Surgery Seoul National University College of Medicine Seoul Korea.) 한원식 (서울대학교병원)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.24 No.6

발행연도: 2021.12

수록면: 520 - 530 (11page)

DOI: 10.4048/jbc.2021.24.e52

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Purpose: The oncoplastic breast-conserving surgery (OPS) technique, combined with the principles of oncological safety and plastic surgery, results in complete tumor resection while preserving the natural appearance of the breast. The purpose of this study was to evaluate the long-term oncological results after OPS compared with conventional breast-conserving surgery (BCS) for early breast cancer. Methods: The medical records of patients who underwent breast cancer surgery and adjuvant radiation therapy at Seoul National University Hospital between 2011 and 2014 were reviewed. Ipsilateral breast tumor recurrence (IBTR)-free survival rate and recurrence-free survival (RFS) rates were compared between the OPS and BCS groups. Results: One-to-one propensity score matching was conducted, yielding 371 patients in each group. The mean tumor distance from the nipple was shorter, and the mean retrieved specimen size and pathologic tumor size, including ductal carcinoma in situ, were larger in the OPS group than in the conventional BCS group (p < 0.001). Surgical margin positivity was not significantly different between the two groups (p = 0.777). The surgical technique was not significantly associated with IBTR (OPS versus conventional BCS, 5-year survival rate, 96.9% vs. 98.6%; p = 0.355) and RFS (5-year survival rate, 92.9% vs. 94.5%; p = 0.357) on the log-rank test. Multivariate analysis revealed that OPS versus conventional BCS was not significantly associated with survival outcomes. Conclusion: We observed no significant differences in long-term IBTR and RFS between the OPS and conventional BCS groups in this retrospective analysis. OPS can be an oncologically and surgically safe alternative option for conventional BCS for early breast cancer.

#Breast Neoplasms #Disease-Free Survival #Mastectomy #Segmental #Reconstructive Surgical Procedures #Treatment Outcome

참고문헌 (30)

참고문헌 신청

Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241

Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347:1227~1232

Asgeirsson KS / 2005 / Oncological and cosmetic outcomes of oncoplastic breast conserving surgery / Eur J Surg Oncol 31:817~823

Clough KB / 1998 / Cosmetic sequelae after conservative treatment for breast cancer : classification and results of surgical correction / Ann Plast Surg 41:471~481

Habibi M / 2018 / Oncoplastic breast reconstruction : should all patients be considered / Surg Oncol Clin N Am 27:167~180

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