Outbreak investigation of pertussis in an elementary school: a case-control study among vaccinated students

유석현; 김준재; Meng-Yu Chen; 진현주; 이현경; 천병철

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자료유형: 학술저널

저자정보: 유석현 (경기도 감염병관리과) 김준재 (경기도 감염병관리과) Meng-Yu Chen (Centers for Disease Control Taiwan) 진현주 (오산보건소) 이현경 (경기도 감염병관리과) 천병철 (고려대학교)

저널정보: 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.7 No.1

발행연도: 2018.1

수록면: 70 - 75 (6page)

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Purpose: A pertussis patient from an elementary school, in Gyeonggi Province, Korea, was notified to public health authority on July 25, 2017. Epidemiologic investigation was conducted to identify the magnitude, possible source of infection and risk factors for this outbreak on August 17, 2017. Materials and Methods: A case was defined as the school student experiencing cough for more than two weeks with or without paroxysmal, whoop, or post-tussive vomiting. Control was defined as the student polymerase chain reaction-negative at the school. School based surveillance was implemented to identify additional cases. Results: From June 29 to August 27, 2017, nine patients of pertussis were identified from an elementary school. Among nine cases, eight were confirmed by polymerase chain reaction positive. All cases had cough, one (11%) had post-tussive vomiting, and one (11%) had fever. Eight cases had macrolide for 7 days in outpatient clinic, and one case admitted in a hospital. There was no significant difference of demographic factors including gender (p=0.49), age group (p=0.97), number of series of vaccination of pertussis (p=0.52), the number of participation of after school activity (p=0.28), and the time elapsed since last vaccination (p=0.42). However, we found the history of contact within the classroom or after-school activity was only the independent risk factor among all the demographic factors collected (odds ratio, 63.61; 95% confidence interval, 4.35 to 930.79). Conclusion: The contributing factor for transmission is associated with the case-contact. Immediate identification of pertussis with use of appropriate diagnostic test may help to avoid a large number of cases.

참고문헌 (19)

참고문헌 신청

Crowcroft NS / 2003 / How best to estimate the global burden of pertussis? / Lancet Infect Dis 3:413~418

Heymann DL / 2008 / Control of communicable diseases manual / American Public Health Association

Choe YJ / 2012 / National pertussis surveillance in South Korea 1955-2011: epidemiological and clinical trends / Int J Infect Dis 16:e850~e854

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이수영 / 2015 / Pertussis Prevalence in Korean Adolescents and Adults with Persistent Cough / Journal of Korean Medical Science 30(7):988~990

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