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자료유형
학술저널
저자정보
Ji Young Chang (Ewha Womans University School of Medicine) Sung-Ae Jung (Ewha Womans University School of Medicine) Chang Mo Moon (Ewha Womans University School of Medicine) Seong-Eun Kim (Ewha Womans University School of Medicine) Hye-Kyung Jung (Ewha Womans University School of Medicine) Ki-Nam Shim (Ewha Womans University School of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.16 No.4
발행연도
2018.1
수록면
599 - 608 (10page)

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Background/Aims: Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in the management of inflammatory bowel disease (IBD) patients. We evaluated immunogenicity for HBV in IBD patients and the response to the HBV vaccination. Methods: From May 2014 to August 2016, patients diagnosed with IBD were prospectively included and evaluated for antibody to hepatitis B surface antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen. Among the 73 patients who were confirmed with nonimmunity to HBV, 44 patients who had completed the 3-dose HBV vaccination series received a single booster vaccination, while 29 patients who had not completed the vaccinations series or were unsure of receiving the vaccination received a full vaccination series. Results: An optimal response was obtained in 70.5% of the patients in the booster group, and 89.7% of the patients in the full vaccination group. Age younger than 26 years (odds ratio [OR], 6.01; 95% confidence interval [CI], 1.15–31.32; P=0.033) and a complete previous vaccination series (OR, 0.15; 95% CI, 0.03–0.80; P=0.026) were associated with optimal vaccine response. Previous complete vaccination series (OR, 0.11; 95% CI, 0.02–0.73; P=0.022) was the only predictive factor for lower compliance. Conclusions: The response to the HBV vaccination was lower in patients older than 26 years and for those patients with a complete vaccination history. Since patients with a complete vaccination history also had poor compliance, serum HBV-titers should be checked more thoroughly, and a full vaccination series should be administered in cases when there is a negative response to the booster vaccination. (Intest Res 2018;16:599-608)

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