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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 351 - 361 (11page)
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Nerve regeneration after injury requires proper axon alignment to bridge the lesion site and myelination to achieve functional recovery. Transplanted scaffolds with aligned channels, have been shown to induce axon growth to some extent. However, the penetration of axons into the microchannels remain a challenge, influencing the functional recovery of regenerated nerves. We previously demonstrated that the size of microchannels exerts significant impact on Schwann cells (SCs) migration. Here we demonstrate that migration of SCs promotes, significantly, the dorsal root ganglion (DRG) neurons to extend axons into three-dimensional channels and form aligned fascicular-like axon tracts. Moreover, the migrating SCs attach and wrap around the aligned axons of DRG neurons in the microchannels and initiate myelination. The SCs release growth factors that provide chemotactic signals to the regenerating axons, similar to the response achieved with nerve growth factor (NGF), but with the additional capability of promoting myelination, thereby demonstrating the beneficial effects of including SCs over NGF alone in enhancing axon penetration and myelination in three-dimensional microchannels.
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참고문헌 (30)
참고문헌 신청
Totoiu MO / 2005 / Spinal cord injury is accompanied by chronic progressive demyelination / J Comp Neurol 486:373~383
Silver J / 2004 / Regeneration beyond the glial scar / Nat Rev Neurosci 5:146~156
Schwab ME / 2004 / Nogo and axon regeneration / Curr Opin Neurobiol 14:118~124
Blesch A / 2009 / Spinal cord injury: plasticity, regeneration and the challenge of translational drug development / Trends Neurosci 32:41~47
Liu C / 2015 / Axonal regeneration and myelination: applicability of the layerby-layer technology. Layer-by-layer films for biomedical Applications / Wiley-VCH Verlag GmbH & Co. KGaA :525~546
Silver J / 2004 / Regeneration beyond the glial scar / Nat Rev Neurosci 5:146~156
Schwab ME / 2004 / Nogo and axon regeneration / Curr Opin Neurobiol 14:118~124
Blesch A / 2009 / Spinal cord injury: plasticity, regeneration and the challenge of translational drug development / Trends Neurosci 32:41~47
Liu C / 2015 / Axonal regeneration and myelination: applicability of the layerby-layer technology. Layer-by-layer films for biomedical Applications / Wiley-VCH Verlag GmbH & Co. KGaA :525~546
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