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논문 기본 정보

자료유형
학술저널
저자정보
Min Kwang Wook (Korea Advanced Institute of Science and Technology) Kim Namsuk (Korea Advanced Institute of Science and Technology) Lee Jae Hoon (Yonsei University) Sung Younghoon (University of Ulsan College of Medicine) Kim Museong (Korea Advanced Institute of Science and Technology) Lee Eun Jung (Korea Advanced Institute of Science and Technology) Kim Jong-Myeong (Korea Advanced Institute of Science and Technology) Kim Jae-Hyun (Korea Advanced Institute of Science and Technology) Lee Jaeyoung (Korea Advanced Institute of Science and Technology) Cho Wonjin (Korea Advanced Institute of Science and Technology) Yang Jee Myung (Dongguk University Ilsan Hospital) Kim Nury (Institute for Basic Science) Kim Jaehoon (Korea Advanced Institute of Science and Technology) Lee C. Justin (Institute for Basic Science (IBS)) Park Young-Gyun (Korea Advanced Institute of Science and Technology) Lee Seung-Hee (Korea Advanced Institute of Science and Technology) Lee Han-Woong (Yonsei University) Kim Jin Woo (Korea Advanced Institute of Science and Technology (KAIST))
저널정보
대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제55권
발행연도
2023.2
수록면
385 - 400 (16page)
DOI
10.1038/s12276-023-00930-4

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초록· 키워드

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In binocular animals that exhibit stereoscopic visual responses, the axons of retinal ganglion cells (RGCs) connect to brain areas bilaterally by forming a commissure called the optic chiasm (OC). Ventral anterior homeobox 1 (Vax1) contributes to the formation of the OC, acting endogenously in optic pathway cells and exogenously in growing RGC axons. Here, we generated Vax1AA/AA mice expressing the Vax1AA mutant, which is incapable of intercellular transfer. We found that RGC axons cannot take up Vax1AA protein from the Vax1AA/AA mouse optic stalk (OS) and grow slowly to arrive at the hypothalamus at a late stage. The RGC axons of Vax1AA/AA mice connect exclusively to ipsilateral brain areas after failing to access the midline, resulting in reduced visual acuity and abnormal oculomotor responses. Overall, our study provides physiological evidence for the necessity of intercellular transfer of Vax1 and the importance of the bilateral RGC axon projection in proper visuomotor responses.

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