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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 139 - 146 (8page)
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Adaptive brain function and synaptic plasticity rely on dynamicregulation of local proteome. One way for the neuronto introduce new proteins to the axon terminal is to transportthose from the cell body, which had long been thought as theonly source of axonal proteins. Another way, which is thetopic of this review, is synthesizing proteins on site by localmRNA translation. Recent evidence indicates that the axonstores a reservoir of translationally silent mRNAs and regulatestheir expression solely by translational control. Different stimulito axons, such as guidance cues, growth factors, and nerve injury,promote translation of selective mRNAs, a process requiredfor the axon’s ability to respond to these cues. One of thecritical questions in the field of axonal protein synthesis is howmRNA-specific local translation is regulated by extracellularcues. Here, we review current experimental techniques that canbe used to answer this question. Furthermore, we discuss hownew technologies can help us understand what biological processesare regulated by axonal protein synthesis in vivo.
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참고문헌 (26)
참고문헌 신청
Andreassi C / 2010 / An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons / Nat Neurosci 13 : 291 ~ 301
Boyden S / 1962 / The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes / J Exp Med 115 : 453 ~ 466
Campbell DS / 2001 / Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation / Neuron 32 : 1013 ~ 1026
Campenot RB / 1977 / Local control of neurite development by nerve growth factor / Proc Natl Acad Sci U S A 74 : 4516 ~ 4519
Dieterich DC / 2006 / Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging(BONCAT) / Proc Natl Acad Sci U
Boyden S / 1962 / The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes / J Exp Med 115 : 453 ~ 466
Campbell DS / 2001 / Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation / Neuron 32 : 1013 ~ 1026
Campenot RB / 1977 / Local control of neurite development by nerve growth factor / Proc Natl Acad Sci U S A 74 : 4516 ~ 4519
Dieterich DC / 2006 / Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging(BONCAT) / Proc Natl Acad Sci U
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