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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 126 - 131 (6page)
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P48 Ebp1 is expressed in rapidly proliferating cells such as cancer cells and accelerates cell growth and survival.
However, its expression pattern and role in central nervous system development have not been studied. Here, we demonstrated the spatiotemporal expression pattern of p48 Ebp1 during embryonic development and the postnatal period.
During embryonic development, p48 Ebp1 was highly expressed in the brain. Expression gradually decreased after birth but was still more abundant than p42 expression after birth. Strikingly, we found that p48 Ebp1 was expressed in a cell type specific manner in neurons but not astrocytes. Moreover, p48 Ebp1 physically interacted with beta tubulin but not alpha tubulin.
This fits with its accumulation in distal microtubule growth cone regions. Furthermore, in injured hippocampal slices, p48 Ebp1 introduction promoted axon regeneration. Thus, we speculate that p48 Ebp1 might contribute to microtubule dynamics acting as an MAP and promotes CNS axon regeneration.
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참고문헌 (24)
참고문헌 신청
Ahn JY / 2006 / Nuclear akt associates with PKCphosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase / EMBO J 25 : 2083 ~ 2095
Bose SK / 2006 / Identification of Ebp1 as a component of cytoplasmic bcl-2 mRNP (messenger ribonucleoprotein particle) complexes / Biochem J 15 : 99 ~ 107
Carlier MF / 1984 / Interference of GTP hydrolysis in the mechanism of microtubule assembly: An experimental study / Proc Natl Acad Sci U S A 81 : 771 ~ 775
Chong VZ / 2008 / Specific developmental reductions in subventricular zone ErbB1 and ErbB4 mRNA in the human brain / Int J Dev Neurosci 26 : 791 ~ 803
Figeac N / 2014 / ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells / Dev Biol 386 : 135 ~ 151
Bose SK / 2006 / Identification of Ebp1 as a component of cytoplasmic bcl-2 mRNP (messenger ribonucleoprotein particle) complexes / Biochem J 15 : 99 ~ 107
Carlier MF / 1984 / Interference of GTP hydrolysis in the mechanism of microtubule assembly: An experimental study / Proc Natl Acad Sci U S A 81 : 771 ~ 775
Chong VZ / 2008 / Specific developmental reductions in subventricular zone ErbB1 and ErbB4 mRNA in the human brain / Int J Dev Neurosci 26 : 791 ~ 803
Figeac N / 2014 / ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells / Dev Biol 386 : 135 ~ 151
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