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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 101 - 113 (13page)
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초록· 키워드
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Osteochondral lesion is a major joint disease in humans. Therefore, this study was designed to investigate the regeneration of articular cartilage and subchondral bone, using three-dimensional constructs of autologous adipose tissuederived mesenchymal stromal cells without any biocompatible scaffolds. Mesenchymal stromal cells were harvested by liposuction from seven pigs, isolated enzymatically, and expanded until construct creation. The pig models had two osteochondral defects (cylindrical defects with a diameter of 5.2 mm and a depth of 5 mm) in one of their patello-femoral grooves. A columnar structure consisting of approximately 770 spheroids of 5 9 104 autologous mesenchymal stromal cells were implanted into one of the defects (implanted defect), while the other defect was not implanted (control). The defects were evaluated pathologically at 6 months (in three pigs) and 12 months (in five pigs) after implantation. At 6 months after surgery, histopathology revealed active endochondral ossification underneath the plump fibrocartilage in the implanted defects, but a deficiency of fibrocartilaginous coverage in the controls. At 12 months after surgery, the fibrocartilage was transforming into hyaline cartilage as thick as the surrounding normal cartilage and the subchondral bone was thickening in the implanted defects. The histological averages of the implanted sites were significantly higher than those in the control sites at both 6 and 12 months after surgery. The implantation of a scaffold-free three-dimensional construct of autologous mesenchymal stromal cells into an osteochondral defect can induce regeneration of hyaline cartilage and subchondral bone structures over a period of 12 months.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Muraki S / 2009 / Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese populationbased cohorts: the ROAD study / Osteoarthritis Cartilage 17:1137~1143
Szerb I / 2005 / Mosaicplasty: longterm follow-up / Bull Hosp Jt Dis 63:54~62
Bentley G / 2003 / A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee / J Bone Joint Surg Br 85:223~230
Fujisato T / 1996 / Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold / Biomaterials 17:155~162
Funayama A / 2008 / Repair of full-thickness articular cartilage defects using injectable type II collagen gel embedded with cultured chondrocytes in a rabbit model / J Orthop Sci 13:225~232
Szerb I / 2005 / Mosaicplasty: longterm follow-up / Bull Hosp Jt Dis 63:54~62
Bentley G / 2003 / A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee / J Bone Joint Surg Br 85:223~230
Fujisato T / 1996 / Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold / Biomaterials 17:155~162
Funayama A / 2008 / Repair of full-thickness articular cartilage defects using injectable type II collagen gel embedded with cultured chondrocytes in a rabbit model / J Orthop Sci 13:225~232
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