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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Isoflavones are biologically active compounds that occur naturally in a variety of plants, with relatively high levels in soybean. Tectorigenin, an isoflavone, protects against hydrogen peroxide (H2O2)-induced cell damage. However, the underlying mechanism is unknown. Methods: The MTT assay was performed to determine cell viability. Catalase activity was assessed by determining the amount of enzyme required to degrade 1 μM H2O2. Protein expression of catalase, phospho-extracellular signal-regulated kinase (ERK), IκB-α, and NF-κB were evaluated by Western blot analysis. A mobility shift assay was performed to assess the DNA-binding ability of NF-κB. Transient transfection and a NF-κB luciferase assay were performed to assess transcriptional activity. Results: Tectorigenin reduced H2O2-induced death of Chinese hamster lung fibroblasts (V79-4). In addition, tectorigenin increased the activity and protein expression of catalase. Blockade of catalase activity attenuated the protective effect of tectorigenin against oxidative stress. Furthermore, tectorigenin enhanced phosphorylation of ERK and nuclear expression of NF-B, while inhibition of ERK and NF-κB attenuated the protective effect of tectorigenin against oxidative stress. Conclusions: Tectorigenin protects cells against oxidative damage by activating catalase and modulating the ERK and NF-κB signaling pathway.
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참고문헌 (29)
참고문헌 신청
Han T / 2012 / In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties / Food Chem Toxicol 50:409~414
Qu J / 2012 / Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin / J Chromatogr B Analyt Technol Biomed Life Sci 902:61~69
Liu M / 2012 / Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities / Molecules 17:6156~6169
Kang KA / 2005 / Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide / Eur J Pharmacol 519:16~23
Lushchak VI / 2015 / Free radicals, reactive oxygen species, oxidative stresses and their classifications / Ukr Biochem J 87:11~18
Qu J / 2012 / Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin / J Chromatogr B Analyt Technol Biomed Life Sci 902:61~69
Liu M / 2012 / Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities / Molecules 17:6156~6169
Kang KA / 2005 / Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide / Eur J Pharmacol 519:16~23
Lushchak VI / 2015 / Free radicals, reactive oxygen species, oxidative stresses and their classifications / Ukr Biochem J 87:11~18
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