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The Anti-inflammatory Effect of Nypa fruticans Wurmb. Fruit on Lipopolysaccharide-induced Inflammatory response on RAW 264.7 cells
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LPS로 유도한 염증반응에서 해죽순의 항염증 효과

논문 기본 정보

Type
Academic journal
Author
Bae, Gi-Sang (원광대학교 한의과대학 본초학교실) Park, Sung-Joo (원광대학교 한의과대학 본초학교실)
Journal
대한본초학회 대한본초학회지(본초분과학회지) 대한본초학회지 제31권 제5호
Published
2016.1
Pages
79 - 84 (6page)

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The Anti-inflammatory Effect of Nypa fruticans Wurmb. Fruit on Lipopolysaccharide-induced Inflammatory response on RAW 264.7 cells
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Abstract· Keywords

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Objective : Nypa fruticans Wurmb. Fruit (NF) has been used as a conventional medicine to treat inflammatory peridontal diseases in Myanmar and Eastern Asia. However, the anti-inflammatory effect of NF aqueous extract on lipopolysaccharide (LPS)-induced inflammatory responses was not well-investigated. Therefore, this study was aimed to investigate the anti-inflammatory effect of NF on LPS-induced inflammatory responses on RAW 264.7 cells.Methods : To induce inflammation on the macrophage cell line, RAW 264.7 cells were treated with 500 ng/mL of LPS. Water extracts of NF was treated 1 h prior to treatment of LPS. Cell viability was measured by MTT assay. Production of nitrite was measured with Griess assay and pro-inflammatory cytokines such as interleukine (IL)-1β and IL-6, and tumor necrosis factor (TNF)-α was measured by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). In addition, we examined the inhibitory mechanisms of NF by western blot and immunocytochemistry.Result : Water Extract from NF itself did not have any cytotoxic effect at the concentration of 200 ㎍/ml in RAW 264.7 cells. Treatment of NF inhibited the production of nitrite, and pro-inflammatory cytokines inlcuding IL-1β, IL-6 and TNF-α in a dose dependant. In addition, NF treatment inhibited the LPS-induced activation and translocation of nuclear factor (NF)-κB.Conclusion : In summary, our result suggest that treatment of NF could reduce the LPS-induced inflammatory responses via deactivation of NF-κB. This study could suggest that NF could be a beneficial drug or agent to prevent inflammation.
#Nypa fruticans Wurmb #Fruit #NF) #lipopolysaccharide #LPS) #RAW264 #7 cells #inflammation #cytokines

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McDaniel ML / 1996 / Cytokines and nitric oxide in islet inflammation and diabetes / Proc Soc Exp Biol Med 211:24~32 google schola 김대희 / 2009 / LPS로 활성화된 대식세포에서 黃連解毒湯 물추출물의 염증매개물질 억제효과 / 대한본초학회지 24(4):39~47 google schola Behrens EM / 2008 / Macrophage activation syndrome in rheumatic disease: What is the role of the antigen presenting cell? / Autoimmunity Reviews 305:305~308 google schola Lopez-Bojorquez LN / 2004 / Molecular mechanisms involved in the pathogenesis of septic shock / Arch Med Res 35:465~479 google schola Athman R / 2004 / Innate immunity via Toll-like receptors and Nod proteins / Curr Opin Microbiol 7:25~32 google schola

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