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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 427 - 433 (7page)
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Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved in synthesis of reduced glutathione (GSH), and investigated the associated upstream signaling cascades. By activating nuclear factor-erythroid 2-related factor (Nrf2), galangin treatment significantly increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS). This activation of Nrf2 depended on extracellular signal-regulated kinases (ERKs) and protein kinase B (AKT) signaling. Inhibition of GSH in galangin-treated cells attenuated the protective effect of galangin against the deleterious effects of UVB. Our results reveal that galangin protects human keratinocytes by activating ERK/AKT-Nrf2, leading to elevated expression of GSH-synthesizing enzymes.
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참고문헌 (25)
참고문헌 신청
Afolayan, A. J. / 1997 / The antimicrobial activity of 3,5,7-trihydroxyflavoneisolated from the shoots of Helichrysum aureonitens / J. Ethnopharmacol 57:177~181
Bolfa, P. / 2013 / Photoprotective effects of Romanian propolis on skin of mice exposed to UVB irradiation / Food Chem. Toxicol 62:329~342
Chen, J. S. / 2011 / Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract / Atherosclerosis 214:301~309
Ciolino, H. P. / 1999 / The flavonoid galangin is an inhibitor of CYP1A1activity and an agonist/antagonist of the aryl hydrocarbon receptor / Br. J. Cancer 79:1340~1346
Copple, I. M. / 2008 / The Nrf2-Keap1 defense pathway: role in protection against drug-induced toxicity / Toxicology 246:24~33
Bolfa, P. / 2013 / Photoprotective effects of Romanian propolis on skin of mice exposed to UVB irradiation / Food Chem. Toxicol 62:329~342
Chen, J. S. / 2011 / Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract / Atherosclerosis 214:301~309
Ciolino, H. P. / 1999 / The flavonoid galangin is an inhibitor of CYP1A1activity and an agonist/antagonist of the aryl hydrocarbon receptor / Br. J. Cancer 79:1340~1346
Copple, I. M. / 2008 / The Nrf2-Keap1 defense pathway: role in protection against drug-induced toxicity / Toxicology 246:24~33
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