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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 167 - 174 (8page)
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Alterations in sulfur amino acid metabolism are associated with an increased risk of a number of common late-life diseases, which raises the possibility that metabolism of sulfur amino acids may change with age. The present study was conducted to understand the age-related changes in hepatic metabolism of sulfur amino acids in 2-, 6-, 18- and 30-month-old male C57BL/6 mice. For this purpose, metabolite profiling of sulfur amino acids from methionine to taurine or glutathione (GSH) was performed. The levels of sulfur amino acids and their metabolites were not significantly different among 2-, 6- and 18-month-old mice, except for plasma GSH and hepatic homocysteine. Plasma total GSH and hepatic total homocysteine levels were significantly higher in 2-month-old mice than those in the other age groups. In contrast, 30-month-old mice exhibited increased hepatic methionine and cysteine, compared with all other groups, but decreased hepatic S-adenosylmethionine (SAM), S-adenosylhomocysteine and homocysteine, relative to 2-month-old mice. No differences in hepatic reduced GSH, GSH disulfide, or taurine were observed. The hepatic changes in homocysteine and cysteine may be attributed to upregulation of cystathionine ${\beta}-synthase$ and down-regulation of ${\gamma}-glutamylcysteine$ ligase in the aged mice. The elevation of hepatic cysteine levels may be involved in the maintenance of hepatic GSH levels. The opposite changes of methionine and SAM suggest that the regulatory role of SAM in hepatic sulfur amino acid metabolism may be impaired in 30-month-old mice.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Andersen, M. L. / 2004 / Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats / Exp. Gerontol. 39:817~824
Anisimov, V. N. / 2010 / Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice / Aging (Albany NY) 2:945~958
Baker, D. H. / 2006 / Comparative species utilization and toxicity of sulfur amino acids / J. Nutr. 136:1670S~1675S
Barja de, Q. G. / 1990 / Anti-oxidant defences and peroxidation in liver and brain of aged rats / Biochem. J. 272:247~250
Benevenga, N. J. / 1984 / Adverse effects of excessive consumption of amino acids / Annu. Rev. Nutr. 4:157~181
Anisimov, V. N. / 2010 / Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice / Aging (Albany NY) 2:945~958
Baker, D. H. / 2006 / Comparative species utilization and toxicity of sulfur amino acids / J. Nutr. 136:1670S~1675S
Barja de, Q. G. / 1990 / Anti-oxidant defences and peroxidation in liver and brain of aged rats / Biochem. J. 272:247~250
Benevenga, N. J. / 1984 / Adverse effects of excessive consumption of amino acids / Annu. Rev. Nutr. 4:157~181
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