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논문 기본 정보

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학술저널
저자정보
Ali Ayhan (Baskent University Faculty of Medicine) Nazlı Topfedaisi Ozkan (Hacettepe University Turkey) Murat Özdemir (Department of Gynecologic Oncology Etlik Zübeyde Hanım Women's Health Training and Research Hospita) Günsu Kimyon Comert (Department of Gynecologic Oncology Zekai Tahir Burak Women's Health Training and Research Hospital) Zeliha Firat Cuylan (Division of Gynecologic Oncology Department of Obstetrics and Gynecology Faculty of Medicine Başk) Gonca Çoban (Department of Gynecologic Oncology Etlik Zübeyde Hanım Women's Health Training and Research Hospita) Osman Turkmen (Kanuni Sultan Suleyman Teaching and Research Hospital) Baki Erdem (University of Health Sciences Ankara) Hanifi Şahin (Kanuni Sultan Suleyman Teaching and Research Hospital) Özgür Akbayır (Gulhane Training and Researh Hospital) Murat Dede (Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital) Ahmet Taner Turan (Baskent University) Husnu Celik (University of Health Sciences Ankara) Tayfun Güngör (Baskent University Faculty of Medicine) Ali Haberal (Cerrahpasa Faculty of Medicine Istanbul University) Macit Arvas (Zekai Tahir Burak Women's Health Training and Research Hospital University of Health Sciences Facul) Mehmet Mutlu Meydanli
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.29 No.4
발행연도
2018.1
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1 - 14 (14page)

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OBJECTIVE: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in women with stage IIIC endometrioid endometrial cancer (EC). METHODS: A multicenter, retrospective department database review was performed to identify patients with stage IIIC pure endometrioid EC at 6 gynecologic oncology centers in Turkey. A total of 207 women were included. LNR, defined as the percentage of positive lymph nodes (LNs) to total nodes recovered, was stratified into 2 groups: LNR1 (≤0.15), and LNR2 (>0.15). Kaplan-Meier method was used to generate survival data. Factors predictive of outcome were analyzed using Cox proportional hazards models. RESULTS: One hundred and one (48.8%) were classified as stage IIIC1 and 106 (51.2%) as stage IIIC2. The median age at diagnosis was 58 (range, 30-82) and the median duration of follow-up was 40 months (range, 1-228 months). There were 167 (80.7%) women with LNR ≤0.15, and 40 (19.3%) women with LNR >0.15. The 5-year progression-free survival (PFS) rates for LNR ≤0.15 and LNR >0.15 were 76.1%, and 58.5%, respectively (p=0.045). An increased LNR was associated with a decrease in 5-year overall survival (OS) from 87.0% for LNR ≤0.15 to 62.3% for LNR >0.15 (p=0.005). LNR >0.15 was found to be an independent prognostic factor for both PFS (hazard ratio [HR]=2.05; 95% confidence interval [CI]=1.07-3.93; p=0.03) and OS (HR=3.35; 95% CI=1.57-7.19; p=0.002). CONCLUSION: LNR seems to be an independent prognostic factor for decreased PFS and OS in stage IIIC pure endometrioid EC.

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참고문헌 (30)

참고문헌 신청
Mariani A / 2001 / Significance of pathologic patterns of pelvic lymph node metastases in endometrial cancer / Gynecol Oncol 80:113~120 Crossref Fleming ND / 2015 / Impact of lymph node ratio and adjuvant therapy in node-positive endometrioid endometrial cancer / Int J Gynecol Cancer 25:1437~1444 Crossref Abu-Rustum NR / 2010 / A nomogram for predicting overall survival of women with endometrial cancer following primary therapy: toward improving individualized cancer care / Gynecol Oncol 116:399~403 Crossref Lachance JA / 2006 / The effect of age on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer / Gynecol Oncol 101:470~475 Crossref Milgrom SA / 2013 / Postoperative external beam radiation therapy and concurrent cisplatin followed by carboplatin/paclitaxel for stage III (FIGO 2009) endometrial cancer / Gynecol Oncol 130:436~440 Crossref

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