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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 19 - 27 (9page)
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Background and Objectives: The impacts of prophylactic central compartment neck dissection (pCCND) on the prognosis of papillary thyroid cancer (PTC) are controversial. The aim of this study is to evaluate the relationship between nodal factors of pCCND and the prognosis of PTC patients. Materials and Methods: A total of 1754 patients who underwent thyroidectomy with pCCND were retrospectively reviewed. Nodal factor was defined as the number of metastatic lymph node (MLN), lymph node yield (LNY) and lymph node ratio (LNR). In regarding the cutoff of nodal factors, patients were categorized as low/high MLN, LNR and LNY group. The correlation of clinicopathologic characteristics including nodal factors and recurrence free survival (RFS) were anlalyzed. Results: Of these, 1195 patients underwent thyroidectomy with unilateral pCCND and 559 patients underwent total thyroidectomy with bilateral pCCND. During follow-up, 45 (2.57%) patients showed recurrent disease. Of these, 19 patients underwent bilateral pCCND and 26 cases were unilateral pCCND. Gross extrathyroidal extension (ETE), high MLN and LNR showed statistically significant on RFS in univariate analysis in unilateral pCCND. In multivariate analysis, gross ETE and high LNR were independent risk factor of recurrence in unilateral pCCND. In bilateral pCCND, larger tumor size, minimal ETE, high MLN and LNR were significant correlation with RFS in univariate analysis. However, in multivariate analysis, multiple larger tumor and high LNR showed significant correlation with RFS. LNY was not statistically significant in both unilateral and bilateral pCCND. Conclusion: In regarding nodal factors, high LNR was only independent risk factor to worse RFS in both unilateral and bilateral pCCND in cN0 PTC patients.
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참고문헌 (30)
참고문헌 신청
Smith PW / 2017 / Sabiston textbook of surgery: The biological basis of modern surgical practice / Elsevier :881~992
Shigematsu N / 2005 / Nationwide survey on the treatment policy for well-differentiated thyroid cancer --results of a questionnaire distributed at the 37th meeting of the Japanese Society of Thyroid Surgery / Endocr J 52(4):479~491
American Thyroid Association Surgery Working Group / 2009 / Consensus statement on the terminology and classification of central neck dissection for thyroid cancer / Thyroid 19(11):1153~1158
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26(1):1~133
Barczynski M / 2013 / Prophylactic central neck dissection for papillary thyroid cancer / Br J Surg 100(3):410~418
Shigematsu N / 2005 / Nationwide survey on the treatment policy for well-differentiated thyroid cancer --results of a questionnaire distributed at the 37th meeting of the Japanese Society of Thyroid Surgery / Endocr J 52(4):479~491
American Thyroid Association Surgery Working Group / 2009 / Consensus statement on the terminology and classification of central neck dissection for thyroid cancer / Thyroid 19(11):1153~1158
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26(1):1~133
Barczynski M / 2013 / Prophylactic central neck dissection for papillary thyroid cancer / Br J Surg 100(3):410~418
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