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논문 기본 정보

자료유형
학술저널
저자정보
Ali Ayhan (Baskent University) Nazlı Topfedaisi Ozkan (Zekai Tahir Burak Women's Health Training and Research Hospital University of Health Sciences Facul) Mustafa Erkan Sarı (Gulhane Military Medicine Academy) Husnu Celik (Baskent University Faculty of Medicine) Murat Dede (Zekai Tahir Burak Women's Health Training and Research Hospital University of Health Sciences Facul) Özgür Akbayır (Cerrahpaşa Medical School 3Institute of Forensic Sciences Istanbul University Istanbul Turkey) Kemal Güngördük Hanifi Şahin Ali Haberal Tayfun Güngör Macit Arvas Mehmet Mutlu Meydanlı
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.29 No.1
발행연도
2018.1
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1 - 10 (10page)

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Objective: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in patients with stage III ovarian high-grade serous carcinoma (HGSC). Methods: A multicenter, retrospective department database review was performed to identify patients with ovarian HGSC at 6 gynecologic oncology centers in Turkey. A total of 229 node-positive women with stage III ovarian HGSC who had undergone maximal or optimal cytoreductive surgery plus systematic lymphadenectomy followed by paclitaxel plus carboplatin combination chemotherapy were included. LNR, defined as the percentage of positive lymph nodes (LNs) to total nodes recovered, was stratified into 3 groups: LNR1 (<10%), LNR2 (10%≤LNR<50%), and LNR3 (≥50%). Kaplan-Meier method was used to generate survival data. Factors predictive of outcome were analyzed using Cox proportional hazards models. Results: Thirty-one women (13.6%) were classified as stage IIIA1, 15 (6.6%) as stage IIIB, and 183 (79.9%) as stage IIIC. The median age at diagnosis was 56 (range, 18–87), and the median duration of follow-up was 36 months (range, 1–120 months). For the entire cohort, the 5-year overall survival (OS) was 52.8%. An increased LNR was associated with a decrease in 5-year OS from 65.1% for LNR1, 42.5% for LNR2, and 25.6% for LNR3, respectively (p<0.001). In multivariate analysis, women with LNR≥0.50 were 2.7 times more likely to die of their tumors (hazard ratio [HR]=2.7; 95% confidence interval [CI]=1.42–5.18; p<0.001). Conclusion: LNR seems to be an independent prognostic factor for decreased OS in stage III ovarian HGSC patients.

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참고문헌 (20)

참고문헌 신청
Qiu HB / 2011 / Ratio of metastatic to resected lymph nodes enhances to predict survival in patients with stage III colorectal cancer / Ann Surg Oncol 18:1568~1574 Crossref Deng J / 2012 / Ratio between negative and positive lymph nodes is suitable for evaluation the prognosis of gastric cancer patients with positive node metastasis / PLoS One 7:e43925 Crossref Chen LJ / 2015 / Ratio and log odds of positive lymph nodes in breast cancer patients with mastectomy / Surg Oncol 24:239~247 Crossref Hou X / 2013 / The positive lymph node ratio predicts long-term survival in patients with operable thoracic esophageal squamous cell carcinoma in China / Ann Surg Oncol 20:1653~1659 Crossref Polterauer S / 2012 / Prognostic value of lymph node ratio and clinicopathologic parameters in patients diagnosed with stage IIIC endometrial cancer / Obstet Gynecol 119:1210~1218 Crossref

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