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논문 기본 정보

자료유형
학술저널
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대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제48권 제2호
발행연도
2016.1
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632 - 640 (9page)

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Purpose The purpose of this study is to compare the prognostic efficacy of the number and location of positive lymph nodes (LN), LN ratio (LNR), and log odds of positive LNs (LODDs) in highrisk cervical cancer treated with radical surgery and adjuvant treatment. Materials and Methods Fifty high-risk patients who underwent radical hysterectomy and pelvic node dissection followed by adjuvant treatment were analyzed retrospectively. The patients had International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IIB. Upper LN is defined as common iliac or higher LN, and LNR is the ratio of positive LNs to harvested LNs. LODDs is log odds between positive LNs and negative LNs. Radiotherapy was delivered to the whole pelvis with median 50.4 Gy/28 Fx± to the para-aortic regions. Platinum-based chemotherapy was used in most patients (93%). The median follow-up duration was 80 months. Results The 5-year disease-free survival (DFS) rate was 76.1%, and the overall survival (OS) rate was 86.4%. Treatment failure occurred in 11 patients, and distant failure (DF) was the dominant pattern (90.9%). In univariate analysis, significantly lower DFS was observed in patients with perineural invasion, ! 2 LN metastases, LNR ! 10%, upper LN metastasis, and ! –1.05 LODDs. In multivariate analysis, ! –1.05 LODDs was the only significant factor for DFS (p=0.011). Of patients with LODDs ! –1.05, 40.9% experienced DF. LODDs was the only significant prognostic factor for OS as well (p=0.006). Conclusion LODDs ! –1.05 was the only significant prognostic factor for both DFS and OS. In patients with LODDs ! –1.05, intensified chemotherapy might be required, considering the high rate of DF.
#Uterine cervical neoplasms #Lymph nodes #Log odds of positive lymph node #Prognosis

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참고문헌 (21)

참고문헌 신청
Rotman M / 2006 / A phase III randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic features : follow-up of a gynecologic oncology group study / Int J Radiat Oncol Biol Phys 65:169~176 google schola Song S / 2012 / 20year experience of postoperative radiotherapy in IB-IIA cervical cancer patients with intermediate risk factors : impact of treatment period and concurrent chemotherapy / Gynecol Oncol 124:63~67 google schola 김우영 / 2009 / Differing prognosis of cervical cancer patients with high risk of treatment failure after radical hysterectomy warrants trial treatment modification / Journal of Gynecologic Oncology 20(1):17~21 dbpia Piura B / 2008 / Recurrent cervical carcinoma after radical hysterectomy and pelvic lymph node dissection : a study of 32 cases / Eur J Gynaecol Oncol 29:31~36 google schola Tsai CS / 1999 / The prognostic factors for patients with early cervical cancer treated by radical hysterectomy and postoperative radiotherapy / Gynecol Oncol 75:328~333 google schola

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