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논문 기본 정보

자료유형
학술저널
저자정보
Hyo Jeong Lee (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Kee Wook Jung (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Sun Ju Chung (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Seung-Mo Hong (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Juyeon Kim (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Jeong Hoon Lee (Asan Medical Center University of Ulsan College of Medicine) Sung Wook Hwang (Asan Medical Center University of Ulsan College of Medicine) Ho-Sung Ryu (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Mi Jung Kim (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Ho-Su Lee (Department of Biochemistry and Molecular Biology University of Ulsan College of Medicine Korea) Myeongsook Seo (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Sang Hyoung Park (Asan Medical Center University of Ulsan College of Medicine) Dong-Hoon Yang (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Byong Duk Ye (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Jeong-Sik Byeon (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Jaewon Choe (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Hwoon-Yong Jung (Asan Medical Center University of Ulsan College of Medicine) Suk-Kyun Yang (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Seung-Jae Myung (Asan Institute for Life Sciences Asan Medical Center Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.3
발행연도
2018.1
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469 - 478 (10page)

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Background/Aims α-Synucleinopathy in the brain is the neuropathological hallmark of Parkinson’s disease (PD). However, the functional impact of α-synucleinopathy in the enteric nervous system remains unknown. We aim to evaluate the association between gastrointestinal (GI) dysfunction and α-synuclein (αSYN) pathology in the stomach and colon of PD patients and controls, as well as to investigate the association between the αSYN pathology in GI tract and future PD risk. Methods A total of 35 PD patients and 52 neurologically intact subjects were enrolled in this study. Endoscopic biopsies were performed, and then immunohistochemical staining for αSYN was performed. All subjects completed the validated Rome III questionnaire for the assessment of GI symptoms. The association between GI symptoms and the αSYN pathology in GI mucosa was evaluated. Incident PD cases were assessed during a median follow-up of 46 months. Results The proportion of self-reported constipation and functional constipation through the Rome III questionnaire was significantly higher in PD patients than in controls (P < 0.001 and P = 0.015). However, no significant association was found between the αSYN pathology in the stomach and colon mucosa and constipation, as well as other GI symptoms including dyspepsia symptoms and abdominal discomfort or pain, regardless of the presence or absence of clinical PD (P > 0.05). No incident PD cases were diagnosed during study period. Conclusions Our present study suggests that the deposition of αSYN in the mucosal enteric nervous system may not be reflected by functional impairment of the affected segment of the gut.

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참고문헌 (36)

참고문헌 신청
Cersosimo MG / 2013 / Gastrointestinal manifestations in parkinson's disease: prevalence and occurrence before motor symptoms / J Neurol 260:1332~1338 Crossref Fasano A / 2015 / Gastrointestinal dysfunction in parkinson's disease / Lancet Neurol 14:625~639 Crossref Spillantini MG / 1997 / Alpha-synuclein in lewy bodies / Nature 388:839~840 Crossref Braak H / 2003 / Staging of brain pathology related to sporadic parkinson's disease / Neurobiol Aging 24:197~211 Crossref Braak H / 2006 / Gastric alpha-synuclein immunoreactive inclusions in meissner's and auerbach's plexuses in cases staged for parkinson's disease-related brain pathology / Neurosci Lett 396:67~72 Crossref

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