지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 488 - 495 (8page)
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초록· 키워드
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Background and Purpose It is essential to develop a reliable predictive serum biomarker for Parkinson’s disease (PD). Te accumulation of alpha-synuclein (αSyn) and up-regulated expression of Rab35 participate in the etiology of PD. Te purpose of this investigation was to determine whether the combined assessment of serum αSyn and Rab35 is a useful predictive biomarker for PD. Methods Serum levels of αSyn or Rab35 were determined in serum samples from 59 sporadic PD patients, 19 progressive supranuclear palsy (PSP) patients, 20 multiple system atrophy (MSA) patients, and 60 normal controls (NC). Receiver operating characteristics (ROC) curves were calculated to determine the diagnostic accuracy of αSyn or/and Rab35 in discriminating PD patients from NC or atypical parkinsonian patients. Results The levels of αSyn and Rab35 were increased in PD patients. The serum level of Rab35 was positively correlated with that of αSyn in PD patients. Compared to analyzing αSyn or Rab35 alone, the combined analysis of αSyn and Rab35 produced a larger area under the ROC curve and performed better in discriminating PD patients from NC, MSA patients, or PSP patients. When age was dichotomized at 55, 60, 65, or 70 years, the combined assessment of αSyn and Rab35 for classifying PD was better in the group below the cutof age than in the group above the cutof age. Conclusions Combined assessment of serum αSyn and Rab35 is a better biomarker for discriminating PD patients from NC or atypical parkinsonian patients, and is a useful predictive biomarker for younger sporadic PD patients.
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참고문헌 (54)
참고문헌 신청
De Lau LM / 2006 / Epidemiology of Parkinson’s disease / Lancet Neurol 5:525~535
Jankovic J / 2008 / Parkinson’s disease : clinical features and diagnosis / J Neurol Neurosurg Psychiatry 79:368~376
Spillantini MG / 1997 / Alpha-synuclein in Lewy bodies / Nature 388:839~840
Burré J / 2015 / The synaptic function of α-synuclein / J Parkinsons Dis 5:699~713
Karpinar DP / 2009 / Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models / EMBO J 28:3256~3268
Jankovic J / 2008 / Parkinson’s disease : clinical features and diagnosis / J Neurol Neurosurg Psychiatry 79:368~376
Spillantini MG / 1997 / Alpha-synuclein in Lewy bodies / Nature 388:839~840
Burré J / 2015 / The synaptic function of α-synuclein / J Parkinsons Dis 5:699~713
Karpinar DP / 2009 / Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models / EMBO J 28:3256~3268
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