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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 50 - 54 (5page)
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초록· 키워드
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Background: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. Methods: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time poly-merase chain reaction assay. Results: The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analy-sis of human parvovirus B19 revealed genotype I in these six patients. Conclusion: In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and dis-ease-prevention measures.
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참고문헌 (30)
참고문헌 신청
Zavattoni M / 2016 / Diagnostic and prognostic value of molecular and serological investigation of human parvovirus B19 infection during pregnancy / New Microbiol 39:181~185
Slavov SN / 2016 / Prevalence and viral load of human parvovirus B19 (B19V) among blood donors in South-East Brazil / Indian J Hematol Blood Transfus 32(Suppl 1):323~325
Kishore J / 2011 / Serological study on parvovirus B19 infection in multitransfused thalassemia major patients and its transmission through donor units / Asian J Transfus Sci 5:140~143
Shabani Z / 2015 / Relation between parvovirus B19 infection and fetal mortality and spontaneous abortion / Med J Islam Repub Iran 29:197
Rogo LD / 2014 / Human parvovirus B19 : a review / Acta Virol 58:199~213
Slavov SN / 2016 / Prevalence and viral load of human parvovirus B19 (B19V) among blood donors in South-East Brazil / Indian J Hematol Blood Transfus 32(Suppl 1):323~325
Kishore J / 2011 / Serological study on parvovirus B19 infection in multitransfused thalassemia major patients and its transmission through donor units / Asian J Transfus Sci 5:140~143
Shabani Z / 2015 / Relation between parvovirus B19 infection and fetal mortality and spontaneous abortion / Med J Islam Repub Iran 29:197
Rogo LD / 2014 / Human parvovirus B19 : a review / Acta Virol 58:199~213
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