지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 167 - 173 (7page)
이용수
초록· 키워드
오류제보하기
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively. Plasmodium vivax was the major infected malaria species in the study samples. Distribution of ABO blood type in the malaria-infected samples was similar to that in healthy subjects, of which blood type O being most prevalent. Association between blood group A and decreased risk of severe malaria was significant. Six thalassemia types (30%) were detected, i.e., hemoglobin E (HbE), β-thalassemia, α-thalassemia 1, α-thalassemia 2, HbE with α-thalassemia 2, and β-thalassemia with α-thalassemia 2. Malaria infected samples without thalassemia showed significantly higher risk to severe malaria. The prevalence of HO-1 polymorphisms, S/S, S/L and L/L were 25, 62, and 13%, respectively. Further study with larger sample size is required to confirm the impact of these 3 host genetic factors in malaria patients.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
[학술지(정기간행물)] - Stevenson M / 2004 / Innate immunity to malaria / Nat Rev Immunol 4 : 169 ~ 180
[학술지(정기간행물)] - Weatherall DJ / 1997 / Thalassaemia and malaria, revisited / Ann Trop Med Parasitol 91 : 885 ~ 890
[학술지(정기간행물)] - Takeda M / 2005 / Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar / Jpn J Infect Dis 58 : 268 ~ 271
[학술지(정기간행물)] - Kuesap J / 2010 / Study on association between genetic polymorphisms of haem oxygenase-1, tumour necrosis factor, cadmium exposure and malaria pathogenicity and severity / Malar J 9 : 260 ~
[학술지(정기간행물)] - Campino S / 2006 / Mendelian and complex genetics of susceptibility and resistance to parasitic infections / Semin Immunol 18 : 411 ~ 422
[학술지(정기간행물)] - Weatherall DJ / 1997 / Thalassaemia and malaria, revisited / Ann Trop Med Parasitol 91 : 885 ~ 890
[학술지(정기간행물)] - Takeda M / 2005 / Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar / Jpn J Infect Dis 58 : 268 ~ 271
[학술지(정기간행물)] - Kuesap J / 2010 / Study on association between genetic polymorphisms of haem oxygenase-1, tumour necrosis factor, cadmium exposure and malaria pathogenicity and severity / Malar J 9 : 260 ~
[학술지(정기간행물)] - Campino S / 2006 / Mendelian and complex genetics of susceptibility and resistance to parasitic infections / Semin Immunol 18 : 411 ~ 422
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UCI(KEPA) : I410-ECN-0101-2018-513-002040267