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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 176 - 179 (4page)
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초록· 키워드
오류제보하기
Rituximab (RTX), a monoclonal antibody against the B-cell marker CD20, is commonly used as a treatment for antibody-mediated diseases or B-lymphocytemediated diseases. Destruction of B cells may reverse the disease course in many conditions; however, patients who are treated with RTX cannot respond appropriately to de novo infection due to lack of B lymphocytes. Here, we report one such case. A 7-year-old renal allograft recipient presented with severe anemia due to parvovirus infection after RTX treatment. The patient had focal segmental glomerulosclerosis and had received cadaveric kidney transplantation 6 months previously. She was treated with high-dose steroid for acute rejection and RTX for Epstein Barr Virus infection 3 months previously. At presentation, her hemoglobin level was 5.4 g/dL and leukocyte and platelet counts were normal. She had microcytic normochromic anemia and high viral load of parvovirus B19(70,578 copies/mL). Intravenous immunoglobulin (200 mg/kg·d) treatment controlled the progression of anemia and parvovirus infection. De novo parvovirus infection during the B lymphocyte-depletion period may have precipitated the severe anemia in this case. Close monitoring of infection is required after RTX therapy.
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등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Becker YT / 2006 / The emerging role of rituximab in organ transplantation / Transpl Int 19 : 621 ~ 628
Comoli P / 2007 / Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation / Am J Transplant 7 : 1648 ~ 1655
Gea-Banacloche JC / 2010 / Rituximab-associated infections / Semin Hematol 47 : 187 ~ 198
Koduri PR / 2000 / Parvovirus B19-related anemia in HIV-infected patients / AIDS Patient Care STDS 14 : 7 ~ 11
Liang TB / 2007 / Pure red cell aplasia due to parvovirus B19 infection after liver transplantation:a case report and review of the literature / World J Gastroenterol 13 : 20
Comoli P / 2007 / Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation / Am J Transplant 7 : 1648 ~ 1655
Gea-Banacloche JC / 2010 / Rituximab-associated infections / Semin Hematol 47 : 187 ~ 198
Koduri PR / 2000 / Parvovirus B19-related anemia in HIV-infected patients / AIDS Patient Care STDS 14 : 7 ~ 11
Liang TB / 2007 / Pure red cell aplasia due to parvovirus B19 infection after liver transplantation:a case report and review of the literature / World J Gastroenterol 13 : 20
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