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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 289 - 295 (7page)
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초록· 키워드
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Purpose: The aim of this study was to investigate and compare the effects of udenafil and mannitol in an experimental renal ischemia-reperfusion (I/R) injury model. Materials and Methods: A total of 64 female Wister Albino rats were used. Right nephrectomy was performed in all groups. In the control group; I/R injury was not performed. In the I/R group; left renal pedicle was clamped for 45 minutes and then underwent 60 minutes and 24 hours of reperfusion. In the mannitol group; 1 mL 20% mannitol was given intravenously 15 minutes before clamping. In the udenafil group; 10-mg/kg udenafil was given orally 1 hour before clamping. Creatinine (Cr), blood urea nitrogen (BUN), Cr clearance, malondialdehyde, neutrophil gelatinase associated lipocalin (NGAL), histological examination and DNA damage (Comet Assay method) levels were compared in tissue, serum and urine samples. Results: Udenafil had a better protective effect than mannitol according to biochemical parameters (Cr, BUN, Cr clearance, and NGAL levels) and histopathological findings when compared with the I/R group. In the Comet sampling analysis no significant difference was detected. Conclusions: Udenafil has a better renoprotective effect than mannitol against I/R injury and this effect supports more functional improvements. Further clinical trials are needed to demonstrate those effects and clinical utility of udenafil for that purpose in humans.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Ahmadiasl N / 2014 / The anti-inflammatory effect of erythropoietin and melatonin on renal ischemia reperfusion injury in male rats / Adv Pharm Bull 4:49~54
Sancaktutar AA / 2014 / The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in male rats / Urol Ann 6:46~50
Legrand M / 2008 / Renal hypoxia and dysoxia after reperfusion of the ischemic kidney / Mol Med 14:502~516
Liangos O / 2006 / Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey / Clin J Am Soc Nephrol 1:43~51
Fadili W / 2013 / Chronic renal allograft dysfunction: risk factors, immunology and prevention / Arab J Nephrol Transplant 6:45~50
Sancaktutar AA / 2014 / The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in male rats / Urol Ann 6:46~50
Legrand M / 2008 / Renal hypoxia and dysoxia after reperfusion of the ischemic kidney / Mol Med 14:502~516
Liangos O / 2006 / Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey / Clin J Am Soc Nephrol 1:43~51
Fadili W / 2013 / Chronic renal allograft dysfunction: risk factors, immunology and prevention / Arab J Nephrol Transplant 6:45~50
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