지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.2
- 발행연도
- 2015.1
- 수록면
- 92 - 99 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury.
Methods: Wistar-Albino rats were divided into three groups that contained seven rats. Group I (sham): Laparotomy and infrarenal abdominal aorta (AA) dissection were done but no clamping was done. Group II (I/R): The infrarenal AA was clamped by atraumatic microvascular clamp for 30 minutes and then was exposed to 90 minutes of reperfusion. Group III (IR + IL-18BP): 75 μg/kg of IL-18BP in 0.9% saline (1 mL) was administered 30 minutes before infrarenal AA dissection and clamping; 30 minutes of ischemia was applied and then was exposed to 90 minutes of reperfusion.
Results: Serum AST, ALT, and LDH levels were remarkably higher in IR group and returned to normal levels in treatment group. The proinflammatory cytokine levels had decreased in treatment group, and was statistically significant compared with the IR group. Serum levels of total oxidant status and oxidative stress index decreased and levels of total antioxidant status increased by IL-18BP.
Conclusion: This study suggested that IL-18BP has antioxidant, anti-inflammatory and hepatoprotective effects in cases of IR with infrarenal AA induced liver oxidative damage.
Methods: Wistar-Albino rats were divided into three groups that contained seven rats. Group I (sham): Laparotomy and infrarenal abdominal aorta (AA) dissection were done but no clamping was done. Group II (I/R): The infrarenal AA was clamped by atraumatic microvascular clamp for 30 minutes and then was exposed to 90 minutes of reperfusion. Group III (IR + IL-18BP): 75 μg/kg of IL-18BP in 0.9% saline (1 mL) was administered 30 minutes before infrarenal AA dissection and clamping; 30 minutes of ischemia was applied and then was exposed to 90 minutes of reperfusion.
Results: Serum AST, ALT, and LDH levels were remarkably higher in IR group and returned to normal levels in treatment group. The proinflammatory cytokine levels had decreased in treatment group, and was statistically significant compared with the IR group. Serum levels of total oxidant status and oxidative stress index decreased and levels of total antioxidant status increased by IL-18BP.
Conclusion: This study suggested that IL-18BP has antioxidant, anti-inflammatory and hepatoprotective effects in cases of IR with infrarenal AA induced liver oxidative damage.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Haimovici H / 1960 / Arterial embolism with acute massive ischemic myopathy and myoglobinuria : evaluation of a hitherto unreported syndrome with report of two cases / Surgery 47 : 739 ~ 747
3. [학술지(정기간행물)] - Clanton TL. / 1999 / Oxidants and skeletal muscle function : physiologic and pathophysiologic implications / Proc Soc Exp Biol Med 222 : 253 ~ 262
4. [학술지(정기간행물)] - Boraschi D. / 2006 / IL-18 in autoimmunity : review / Eur Cytokine Netw 17 : 224 ~ 252
5. [학술지(정기간행물)] - Banda NK. / 2003 / Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein / J Immunol 170 : 2100 ~ 2105
6. [학술지(정기간행물)] - O'Brien LC. / 2014 / Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure / Mol Med 20 : 221 ~ 229
3. [학술지(정기간행물)] - Clanton TL. / 1999 / Oxidants and skeletal muscle function : physiologic and pathophysiologic implications / Proc Soc Exp Biol Med 222 : 253 ~ 262
4. [학술지(정기간행물)] - Boraschi D. / 2006 / IL-18 in autoimmunity : review / Eur Cytokine Netw 17 : 224 ~ 252
5. [학술지(정기간행물)] - Banda NK. / 2003 / Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein / J Immunol 170 : 2100 ~ 2105
6. [학술지(정기간행물)] - O'Brien LC. / 2014 / Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure / Mol Med 20 : 221 ~ 229
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
왼온엉덩동맥 허혈 후 재관류 시간경과에 따른 생쥐의 혈청 내 친염증성 cytokine의 변화
해부·생물인류학
2016 .03
-
Ischemia reperfusion injury of liver and development of an experimental platform
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Journal of Yeungnam Medical Science
2023 .04
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
Analysis of Serum Cytokine Profile in Pemphigus
Annals of Dermatology
2017 .01
-
2시간 허혈 후 재관류 시간 경과에 따라 나타나는 혈청 사이토카인의 발현에 미치는 허혈양상화의 효과
해부·생물인류학
2016 .06
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
Association Analysis of Interleukin-1β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus
Journal of Clinical Neurology
2019 .01
-
Association of Single Nucleotide Polymorphisms in Interleukin-12 Receptor (IL-12Rβ1 and IL-12Rβ2) with Asthma in a Korean Population
대한의생명과학회지
2020 .12
-
Effect of scaling and root planing on the expression of anti-inflammatory cytokines (IL-4, IL-9, IL-10, and IL-13) in the gingival crevicular fluid of electronic cigarette users and non-smokers with moderate chronic periodontitis
Journal of Periodontal & Implant Science
2020 .01
-
Expression of Il4rα and Il13rα1 in Gallbladder Cancer
대한외과학회 학술대회 초록집
2021 .11
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
IL-24 Contributes to Neutrophilic Asthma in an IL-17A-Dependent Manner and Is Suppressed by IL-37
Allergy, Asthma & Immunology Research
2022 .09
-
Protective effect of ischemic postconditioning against hepatic ischemic reperfusion injury in rat liver
Annals of Surgical Treatment and Research
2015 .04
-
Effects of hyperbaric oxygen and iloprost on intestinal ischemia-reperfusion induced acute lung injury
Annals of Surgical Treatment and Research
2019 .01
-
Inflammatory Cytokines and Their Prognostic Ability in Cases of Major Burn Injury
Annals of Laboratory Medicine
2015 .01
-
Mucosal Immunity Related to FOXP3+ Regulatory T Cells, Th17 Cells and Cytokines in Pediatric Inflammatory Bowel Disease
Journal of Korean Medical Science
2018 .01
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-514-001071650