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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 117 - 127 (11page)
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Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity. Recent studies have demonstrated involvement of cilia-related cellular signaling pathways in transducing metabolic information in hypothalamic neurons and in determining cellular fate during adipose tissue development. In this review, we summarize the current knowledge about cilia and cilia-associated signaling pathways in the regulation of body metabolism.
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참고문헌 (60)
참고문헌 신청
Bhurosy T / 2014 / Overweight and obesity epidemic in developing countries: a problem with diet, physical activity, or socioeconomic status? / Scientific World Journal 2014:964236
Hruby A / 2015 / The epidemiology of obesity: a big picture / Pharmacoeconomics 33:673~689
Maes HH / 1997 / Genetic and environmental factors in relative body weight and human adiposity / Behav Genet 27:325~351
Oh EC / 2015 / Metabolic regulation and energy homeostasis through the primary Cilium / Cell Metab 21:21~31
Kebede MA / 2014 / Insights into obesity and diabetes at the intersection of mouse and human genetics / Trends Endocrinol Metab 25:493~501
Hruby A / 2015 / The epidemiology of obesity: a big picture / Pharmacoeconomics 33:673~689
Maes HH / 1997 / Genetic and environmental factors in relative body weight and human adiposity / Behav Genet 27:325~351
Oh EC / 2015 / Metabolic regulation and energy homeostasis through the primary Cilium / Cell Metab 21:21~31
Kebede MA / 2014 / Insights into obesity and diabetes at the intersection of mouse and human genetics / Trends Endocrinol Metab 25:493~501
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