지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
The primary cilium is an organelle which consists of a microtubule in the core and a surrounding cilia membrane, and has long been recognized as a “vestigial organelle”. However, new evidence demonstrates that the primary cilium has a notable effect on signal transduction in the cell and is associated with some genetic and non-genetic diseases. In the kidney, the primary cilium protrudes into the Bowman’s space and the tubular lumen from the apical side of epithelial cells. The length of primary cilia is dynamically altered during the normal cell cycle, being shortened by retraction into the cell body at the entry of cell division and elongated at differentiation. Furthermore, the length of primary cilia is also dynamically changed in the cells, as a result and/or cause, during the progression of various kidney diseases including acute kidney injury and chronic kidney disease. Notably, recent data has demonstrated that the shortening of the primary cilium in the cell is associated with fragmentation, apart from retraction into the cell body, in the progression of diseases and that the fragmented primary cilia are released into the urine. This data reveals that the alteration of primary cilia length could be related to the progression of diseases. This review will consider if primary cilia length alteration is associated with the progression of kidney diseases and if the length of tissue primary cilia and the presence or increase of cilia proteins in the urine is indicative of kidney diseases
목차
등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Satir P / 2007 / Overview of structure and function of mammalian cilia / Annu Rev Physiol 69:377~400
Satir P / 2010 / The primary cilium at a glance / J Cell Sci 123:499~503
Praetorius HA / 2005 / A physiological view of the primary cilium / Annu Rev Physiol 67:515~529
Boletta A / 2003 / Role of polycystins in renal tubulogenesis / Trends Cell Biol 13:484~492
Verghese E / 2009 / Renal primary cilia lengthen after acute tubular necrosis / J Am Soc Nephrol 20:2147~2153
Satir P / 2010 / The primary cilium at a glance / J Cell Sci 123:499~503
Praetorius HA / 2005 / A physiological view of the primary cilium / Annu Rev Physiol 67:515~529
Boletta A / 2003 / Role of polycystins in renal tubulogenesis / Trends Cell Biol 13:484~492
Verghese E / 2009 / Renal primary cilia lengthen after acute tubular necrosis / J Am Soc Nephrol 20:2147~2153
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase
The Korean Journal of Physiology & Pharmacology
2021 .10
-
High water intake induces primary cilium elongation in renal tubular cells
Kidney Research and Clinical Practice
2024 .05
-
Shortening of primary cilia length is associated with urine concentration in the kidneys
Kidney Research and Clinical Practice
2023 .05
-
Primary Cilia as a Signaling Platform for Control of Energy Metabolism
Diabetes and Metabolism Journal
2018 .01
-
Tumor growth with di-(2-ethylhexyl) phthalate is regulated by primary cilium formation through H2O2 production-mediated thymosin β4 gene expression
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Ventromedial hypothalamic primary cilia control energy and skeletal homeostasis
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Primary cilia as a critical cellular organelle of hypothalamic function
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Tissue-specific ciliary function in mouse development
한국실험동물학회 학술발표대회 논문집
2018 .07
-
콩팥 세관에서 주사전자현미경을 이용한 일차섬모의 길이 비교 연구
해부·생물인류학
2024 .12
-
T helper 17 cells in the pathophysiology of acute and chronic kidney disease
Kidney Research and Clinical Practice
2021 .01
-
Sonographic Growth Charts for Kidney Length in Normal Korean Children: A Prospective Observational Study
Journal of Korean Medical Science
2016 .01
-
The association between acute kidney injury in renal infarction and progression to chronic kidney disease
Kidney Research and Clinical Practice
2016 .01
-
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Clinical Genetic Testing in Children with Kidney Disease
Childhood Kidney Diseases
2021 .01
-
Prevalence of Chronic Kidney Disease in Korea: the Korean National Health and Nutritional Examination Survey 2011-2013
Journal of Korean Medical Science
2016 .01
-
Nephronophthisis
Childhood Kidney Diseases
2015 .01
-
Recognizing the importance of physical activity on sarcopenia in chronic kidney disease
Osteoporosis and Sarcopenia
2022 .03
-
Cerebral Small Vessel Disease and Chronic Kidney Disease
대한뇌졸중학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0