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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 145 - 151 (7page)
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Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a strong correlation between circulating FGF21 levels and the incidence and severity of atherosclerosis. Animal studies have demonstrated a beneficial role of FGF21 in protecting against aberrant lipid profile, while recent development in FGF21 mimetics has provided further insight into the lipid-lowering effects of FGF21 signaling. The present review summarizes the physiological roles of FGF21, and discusses major breakthroughs and limitations of FGF21 mimetic-based therapeutic strategies for treating atherosclerosis.
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참고문헌 (55)
참고문헌 신청
Beenken A / 2009 / The FGF family: biology, pathophysiology and therapy / Nat Rev Drug Discov 8:235~253
Kurosu H / 2007 / Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 / J Biol Chem 282:26687~26695
Woo YC / 2013 / Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives / Clin Endocrinol (Oxf) 78:489~496
Gimeno RE / 2014 / FGF21-based pharmacotherapy: potential utility for metabolic disorders / Trends Endocrinol Metab 25:303~311
Yang C / 2012 / Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB / PLoS One 7:e33870
Kurosu H / 2007 / Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 / J Biol Chem 282:26687~26695
Woo YC / 2013 / Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives / Clin Endocrinol (Oxf) 78:489~496
Gimeno RE / 2014 / FGF21-based pharmacotherapy: potential utility for metabolic disorders / Trends Endocrinol Metab 25:303~311
Yang C / 2012 / Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB / PLoS One 7:e33870
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한국 제2형 당뇨병 남성에서FGF-21과 비알코올성 지방간의 연관성
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2015 .01
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Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes
Journal of Korean Medical Science
2015 .01
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Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
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2018 .01
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Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways
Gut and Liver
2018 .01
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Acquired Forms of Fibroblast Growth Factor 23-Related Hypophosphatemic Osteomalacia
Endocrinology and Metabolism
2024 .04
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Relationship Between the Serum FGF21 Level and Growth in Children of Short Stature
Journal of Korean Medical Science
2023 .02
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Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers
Annals of Pediatirc Endocrinology & Metabolism
2021 .12
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Activating transcription factor 4 aggravates angiotensin II-induced cell dysfunction in human vascular aortic smooth muscle cells via transcriptionally activating fibroblast growth factor 21
The Korean Journal of Physiology & Pharmacology
2022 .09
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High Dose of FGF-2 Induced Growth Retardation via ERK1/2 De-phosphorylation in Bone Marrow-derived Mesenchymal Stem Cells
대한의생명과학회지
2017 .06
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The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application
Clinical and Experimental Otorhinolaryngology
2017 .01
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Maintenance of Proliferation and Adipogenic Differentiation by Fibroblast Growth Factor-2 and Dexamethasone Through Expression of Hepatocyte Growth Factor in Bone Marrow-derived Mesenchymal Stem Cells
대한의생명과학회지
2016 .03
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Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor-21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model
Endocrinology and Metabolism
2021 .01
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Hepatic PTPA ameliorates high-fat diet-induced hepatosteatosis and disruption of glucose homeostasis by the activation of the FGF21
한국실험동물학회 학술발표대회 논문집
2022 .07
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PTD-FGF2 attenuates porcine pancreatic elastase induced emphysema in mice
한국실험동물학회 학술발표대회 논문집
2023 .02
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Fibroblast Growth Factor 21 Attenuates Diabetes- Induced Renal Fibrosis by Negatively Regulating TGF- β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
Diabetes and Metabolism Journal
2020 .01
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Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study
Yonsei Medical Journal
2018 .01
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Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice
Diabetes and Metabolism Journal
2020 .01
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Localization of Oncogenic Osteomalacia by Systemic Venous Sampling of Fibroblast Growth Factor 23
Yonsei Medical Journal
2017 .01
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Oral recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of DbDb mice through the activity of brown adipose tissue
한국실험동물학회 학술발표대회 논문집
2019 .07
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Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients
Journal of Clinical Neurology
2020 .01
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