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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제10권 제4호
- 발행연도
- 2017.1
- 수록면
- 349 - 356 (8page)
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초록· 키워드
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Objectives. This study assessed the regenerative efficacy of basic fibroblast growth factor (FGF) in a rabbit model of chronic vocal fold scarring and then confirmed its utility and safety in a prospective trial of patients with this condition.
Methods. FGF was injected three times, at 1-week intervals, into a chronic vocal fold scar created in a rabbit model. After 1 month, mRNA level of procollagen I, hyaluronic acid synthetase 2 (HAS 2), and matrix metalloproteinase 2 (MMP 2) were analyzed by real-time polymerase chain reaction. The relative densities of hyaluronic acid (HA) and collagen were examined 3 months post-injection. From April 2012 to September 2014, a prospective clinical trial was conducted at a tertiary hospital in Korea. FGF was injected into the mild vocal fold scar of 17 consecutive patients with a small glottic gap. The patients underwent perceptual, stroboscopic, acoustic aerodynamic test, and Voice Handicap Index (VHI) survey prior to and 3, 6, and 12 months after FGF injection.
Results. FGF injection of the vocal fold scar decreased the density of collagen and increased mRNA level of HAS 2 and MMP 2 expression significantly compared to the control group injected with phosphate buffered solution in a rabbit model (P<0.05). In the clinical trial, significant improvements in the majority of the subjective and objective voice parameters were registered 3 months after FGF injection and were maintained at 12 months. Complications associated with the FGF injections, such as granuloma, were not observed during the follow-up period.
Conclusion. Based on the animal model and the prospective clinical trial, vocal fold injections of FGF in patients with mild chronic vocal fold scarring can significantly improve voice quality for as long as 1 year and without side effects. Our results recommend the use of FGF vocal fold injection as an alternative treatment modality for mild chronic vocal fold scarring.
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참고문헌 (22)
참고문헌 신청
Dailey SH / 2006 / Surgical management of sulcus vocalis and vocal fold scarring / Otolaryngol Clin North Am 39 (1) : 23 ~ 42
Heldin P / 1989 / Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts / Biochem J 258 (3) : 919 ~ 922
Hirano M. / 1981 / Clinical examination of voice / Springer-Verlag
Hirano S / 2003 / Effect of growth factors on hyaluronan production by canine vocal fold fibroblasts / Ann Otol Rhinol Laryngol 112 (7) : 617 ~ 624
Hirano S / 2003 / Roles of hepatocyte growth factor and transforming growth factor beta1 in production of extracellular matrix by canine vocal fold fibroblasts / Laryngoscop
Heldin P / 1989 / Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts / Biochem J 258 (3) : 919 ~ 922
Hirano M. / 1981 / Clinical examination of voice / Springer-Verlag
Hirano S / 2003 / Effect of growth factors on hyaluronan production by canine vocal fold fibroblasts / Ann Otol Rhinol Laryngol 112 (7) : 617 ~ 624
Hirano S / 2003 / Roles of hepatocyte growth factor and transforming growth factor beta1 in production of extracellular matrix by canine vocal fold fibroblasts / Laryngoscop
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