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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 586 - 590 (5page)
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The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 levels were significantly correlated with GS (r = 0.358, P < 0.001) and ES (r = 0.324, P < 0.001) in univariate analysis with all patients. After adjusting for several confounding factors, both GS and ES were associated with FGF-21 in all patients (r = 0.271, P = 0.014; r = 0.217, P = 0.041, respectively). However, FGF-21 lost significant correlation with both GS and ES with type 2 diabetes mellitus in the final model. The patients with type 2 diabetes mellitus and CAD feature had elevated FGF-21 levels. Despite of a limited role in diabetic patients, FGF-21 levels are independently associated with angiographic severity and extent of CAD.
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참고문헌 (18)
참고문헌 신청
Itoh N / 2004 / Evolution of the Fgf and Fgfr gene families / Trends Genet 20:563~569
Presta M / 2005 / Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis / Cytokine Growth Factor Rev 16:159~178
Nishimura T / 2000 / Identification of a novel FGF, FGF-21, preferentially expressed in the liver / Biochim Biophys Acta 1492:203~206
Lin Z / 2010 / Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile / PLoS One 5:e15534
Kharitonenkov A / 2005 / FGF-21 as a novel metabolic regulator / J Clin Invest 115:1627~1635
Presta M / 2005 / Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis / Cytokine Growth Factor Rev 16:159~178
Nishimura T / 2000 / Identification of a novel FGF, FGF-21, preferentially expressed in the liver / Biochim Biophys Acta 1492:203~206
Lin Z / 2010 / Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile / PLoS One 5:e15534
Kharitonenkov A / 2005 / FGF-21 as a novel metabolic regulator / J Clin Invest 115:1627~1635
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