Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers

Domouzoglou Eleni M.; Vlahos Antonios P.; Cholevas Vasileios  K.; Papafaklis Michail I.; Chaliasos Nikolaos; Siomou Ekaterini; Michalis Lampros K.; Tsatsoulis Agathocles; Naka Katerina K.

doi:10.6065/apem.2040258.129

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자료유형: 학술저널

저자정보: Domouzoglou Eleni M. (Faculty of Medicine School of Health Sciences University of Ioannina) Vlahos Antonios P. (Faculty of Medicine School of Health Sciences University of Ioannina) Cholevas Vasileios K. (Faculty of Medicine School of Health Sciences University of Ioannina) Papafaklis Michail I. (Faculty of Medicine School of Health Sciences University of Ioannina) Chaliasos Nikolaos (Faculty of Medicine School of Health Sciences University of Ioannina) Siomou Ekaterini (Faculty of Medicine School of Health Sciences University of Ioannina) Michalis Lampros K. (Faculty of Medicine School of Health Sciences University of Ioannina) Tsatsoulis Agathocles (Faculty of Medicine School of Health Sciences University of Ioannina) Naka Katerina K. (Faculty of Medicine School of Health Sciences University of Ioannina)

저널정보: 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism 제26권 제4호

발행연도: 2021.12

수록면: 242 - 251 (10page)

DOI: 10.6065/apem.2040258.129

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Purpose: Metabolic and cardiovascular disease prevention starting in childhood is critical for reducing morbidity later in life. In the present study, the association of novel biomarkers with metabolic syndrome (MS) and vascular function/structure indices of early atherosclerosis in children was investigated.Methods: This was a prospective study of 78 children (8?16 years of age) grouped based on the presence or absence of MS. The serum biomarkers investigated included fibroblast growth factor 21 (FGF21), leptin, adiponectin, and insulinlike growth factor binding protein-1 (IGFBP1). Endothelial function and carotid atherosclerosis were assessed based on brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness, respectively.Results: Children with MS (n=12) had higher levels of FGF21 (median [interquartile range]: 128 [76?189] pg/mL vs. 60 [20?98] pg/mL, P=0.003) and leptin (18.1 [11?34.8] pg/mL vs. 7.5 [1.9?16.5] ng/mL, P=0.003), and lower levels of IGFBP1 (1.5 [1.2?2.1] ng/mL vs. 2.3 [1.5?6] ng/mL, P=0.028) compared with children without MS. FMD inversely correlated with FGF21 (Spearman rho= -0.24, P=0.035) and leptin (rho= -0.24, P=0.002) in all children. The best cutoff value of FGF21 levels for MS diagnosis was above 121.3 pg/mL (sensitivity/specificity, 58/86%). Only FGF21 was significantly associated with the presence of MS after adjustment for body mass index, age, and sex (odds ratio per 10 pg/mL increase: 1.10 [95% confidence interval, 1.01?1.22]; P=0.043).Conclusion: Increased FGF21 levels were associated with the presence of MS and worse endothelial function in children. Larger studies are needed to evaluate the potential value of FGF21 as a biomarker that could predict future metabolic/cardiovascular disease at an early stage.

#Metabolism #Obesity #Fibroblast growth factor 21 #Metabolic syndrome #Leptin #Flow-mediated dilation

참고문헌 (40)

참고문헌 신청

Fon Tacer K / 2010 / Research resource : comprehensive expression atlas of the fibroblast growth factor system in adult mouse / Mol Endocrinol 24:2050~2064

Markan KR / 2014 / Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding / Diabetes 63:4057~4063

Ogawa Y / 2007 / BetaKlotho is required for metabolic activity of fibroblast growth factor 21 / Proc Natl Acad Sci U S A 104:7432~7437

Kurosu H / 2007 / Tissue-specific expression of betaKlotho and fibroblast growth factor(FGF)receptor isoforms determines metabolic activity of FGF19 and FGF21 / J Biol Chem 282:26687~26695

Domouzoglou EM / 2015 / Fibroblast growth factors in cardiovascular disease : The emerging role of FGF21 / Am J Physiol Heart Circ Physiol 309:H1029~H1038

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