지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 485 - 494 (10page)
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초록· 키워드
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Background Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive disease. Most cancer diagnoses are determined by anatomical histology. Therefore, many samples are stored in FFPE blocks for H&E staining. However, RNAs extracted from the FFPE block have a high level of fragmentation, making it difficult to perform accurate DEG analysis using RNA sequencing. Objective To overcome fragmented RNA’s drawback in NGS application, we applied the NanoString nCounter® technique of hybridization method that can be used for DEG analysis without PCR amplification. Methods We characterized the gene expression profiling of AITLs though transcriptome analysis based on the nCounter® PanCancer IO 360™ Panel and NanoString platform. To perform the analysis of differential expression gene (DEG) profiles in AITLs, we compared the NanoString data from eight AITL patients with a healthy control donor. Results Ninety-one genes were up-regulated and six genes were down-regulated in AITLs compared to control. The Gene Ontology (GO) analysis of 97-DEGs revealed that they were closely related to cytokine, MAPK cascade, leukocyte differentiation, and immune response, suggesting that this affect the immune system. In addition, KEGG analysis revealed that AITL DEGs were found to be highly involved in cytokine–cytokine receptor interaction and PI3K-Akt signaling pathway. Conclusion We believe that comprehensive multiplex studies, along with NanoString analysis, may be helpful to understand the molecular mechanisms of AITL, including mutations, gene expression, and protein expression studies.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Boddicker RL / 2019 / Genetic alterations affecting GTPases and T-cell receptor signaling in peripheral T-cell lymphomas / Small GTPases 10:33~39
Broccoli A / 2017 / Angioimmunoblastic T-cell lymphoma / Hematol Oncol Clin North Am 31:223~238
Bustelo XR / 2007 / GTP-binding proteins of the Rho/Rac family : regulation, effectors and functions in vivo / BioEssays 29:356~370
Chiba S / 2015 / G17V RHOA : genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells / Small GTPases 6:100~103
Chihara D / 2017 / The survival outcome of patients with relapsed/refractory peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma / Br J Haematol 176:750~758
Broccoli A / 2017 / Angioimmunoblastic T-cell lymphoma / Hematol Oncol Clin North Am 31:223~238
Bustelo XR / 2007 / GTP-binding proteins of the Rho/Rac family : regulation, effectors and functions in vivo / BioEssays 29:356~370
Chiba S / 2015 / G17V RHOA : genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells / Small GTPases 6:100~103
Chihara D / 2017 / The survival outcome of patients with relapsed/refractory peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma / Br J Haematol 176:750~758
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