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논문 기본 정보

자료유형
학술저널
저자정보
Song Yanyan (College of Biochemical Engineering, Beijing Union University, Beijing 100023, P.R. China) Zhang Jing (College of Biochemical Engineering, Beijing Union University, Beijing 100023, P.R. China) Li Yidan (College of Biochemical Engineering, Beijing Union University, Beijing 100023, P.R. China) Wang Yuxuan (College of Biochemical Engineering, Beijing Union University, Beijing 100023, P.R. China) Wan Yingxin (College of Biochemical Engineering, Beijing Union University, Beijing 100023, P.R. China)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.6
발행연도
2024.6
수록면
1,328 - 1,339 (12page)
DOI
10.4014/jmb.2312.12051

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초록· 키워드

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Cadmium (Cd) is a prevalent environmental contaminant that poses a potential hazard to the health of both humans and animals. In this study, biosynthesized selenium-enriched Lactobacillus plantarum and selenium nanoparticles (SeNPs) were developed and evaluated for their protective effects against Cd-induced hepatic injury in mice through oral administration for 4 weeks. Cadmium exposure resulted in severe impairment of liver function, as evidenced by increased levels of serum markers of liver injury and, oxidative stress and significant damage to liver tissue, and a notable decrease in the diversity of the intestinal microbiota. Oral administration of Se-enriched L. plantarum (LS) reduced cadmium accumulation in the liver by 49.5% and, restored other cadmium-induced damage markers to normal levels. A comparison of the effects with those of L. plantarum (L) and SeNPs isolated from LS revealed that LS could more effectively alleviate hepatic oxidative stress and reduce the intrahepatic inflammatory responses of the liver, further protecting against cadmiuminduced liver injury. These findings suggest that the development of LS may be effective at protecting the liver and intestinal tract from cadmium-induced damage.

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