지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 566 - 572 (7page)
이용수
초록· 키워드
오류제보하기
Peripheral nerve injuries are commonly encountered clinical problem and often result in chronic pain and severe functional deficit. Diosgenin is a plant steroidal saponin and has anti-inflammatory and anticancer effects. In the present study, we investigated the effect of diosgenin on functional recovery following sciatic crushed nerve injury in rats. Walk-ing track analysis for the functional recovery which can be quantified with the sciatic function index (SFI) was conducted. Immunohistochem-istry for c-Fos in the ventrolateral periaqueductal gray (vlPAG) and paraventricular nucleus (PVN) and western blot for brain-derived neu-rotrophic factor (BDNF), tyrosine kinase B (TrkB), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthesis (iNOS) in the sciatic nerve were performed. The right sciatic nerve was crushed for 30 sec using a surgical clip. The animals in the diosgenin-treated groups received oral-ly once a day at the respective doses for 7 consecutive days, starting one day after surgery. Sciatic crushed nerve injury showed character-istic gait changes showing decrease of SFI value. Diosgenin treatment increased the SFI value and suppressed nerve injury-induced c-Fos ex-pression in the vlPAG and PVN. Diosgenin treatment inhibited nerve in-jury-induced increase of BDNF, TrkB, COX-2, and iNOS expressions. It is possible that diosgenin can be used as the new therapeutic agent for pain control and functional recovery following peripheral nerve injury.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Alba E / 2006 / Serum endostatin and bFGF as predictive factors in advanced breast cancer patients treated with letrozole / Clin Transl Oncol 8:193~199
Au AL / 2004 / Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine isolated left anterior descending coronary artery by diosgenin / Eur J Pharmacol 502:123~133
Baba H / 2001 / Direct activation of rat spinal dorsal horn neurons by prostaglandin E2 / J Neurosci 21:1750~1756
백상빈 / 2016 / Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells / International Neurourology Journal 20(4):296~303
Byun YH / 2005 / Treadmill running promotes functional recovery and decreases brain-derived neurotrophic factor mRNA expression following sciatic crushed nerve injury in rats / J Sports Med Phys Fitness 45:222~228
Au AL / 2004 / Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine isolated left anterior descending coronary artery by diosgenin / Eur J Pharmacol 502:123~133
Baba H / 2001 / Direct activation of rat spinal dorsal horn neurons by prostaglandin E2 / J Neurosci 21:1750~1756
백상빈 / 2016 / Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells / International Neurourology Journal 20(4):296~303
Byun YH / 2005 / Treadmill running promotes functional recovery and decreases brain-derived neurotrophic factor mRNA expression following sciatic crushed nerve injury in rats / J Sports Med Phys Fitness 45:222~228
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