지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 296 - 303 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Rocuronium bromide is a nondepolarizing neuromuscular blocking drug and has been used as an adjunct for relaxation or paralysis of the skeletal muscles, facilitation of endotracheal intubation, and improving surgical conditions during general anesthesia. However, intravenous injection of rocuronium bromide induces injection pain or withdrawal movement.
The exact mechanism of rocuronium bromide-induced injection pain or withdrawal movement is not yet understood. We investigated whether rocuronium bromide treatment is involved in the induction of inflammation and pain in vascular endothelial cells.
Methods: For this study, calf pulmonary artery endothelial (CPAE) cells were used, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, Western blot, nitric oxide detection, and prostaglandin E2 immunoassay were conducted.
Results: Rocuronium bromide treatment inhibited endothelial nitric oxide synthase and suppressed nitric oxide production in CPAE cells. Rocuronium bromide activated cyclooxygenase-2, inducible nitric oxide synthase and increased prostaglandin E2 synthesis in CPAE cells.
Conclusions: Rocuronium bromide induced inflammation and pain in CPAE cells. Suppressing nitric oxide production and enhancing prostaglandin E2 synthesis might be associated with rocuronium bromide-induced injection pain or withdrawal movement.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Borgeat A / 1997 / Spontaneous movements associated with rocuronium: is pain on injection the cause? / Br J Anaesth 79:382~383
Bowman WC / 2006 / Neuromuscular block / Br J Pharmacol 147(Suppl 1):S277~S286
Shevchenko Y / 1999 / The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents / Anesth Analg 88:746~748
Klement W / 1991 / Pain on i.v. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations / Br J Anaesth 66:189~195
이호준 / 2009 / Antihistamine Pretreatment to Reduce Incidence of Withdrawal Movement After Rocuronium Injection / Journal of Korean Medical Science 24(5):879~882
Bowman WC / 2006 / Neuromuscular block / Br J Pharmacol 147(Suppl 1):S277~S286
Shevchenko Y / 1999 / The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents / Anesth Analg 88:746~748
Klement W / 1991 / Pain on i.v. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations / Br J Anaesth 66:189~195
이호준 / 2009 / Antihistamine Pretreatment to Reduce Incidence of Withdrawal Movement After Rocuronium Injection / Journal of Korean Medical Science 24(5):879~882
이 논문의 저자 정보
최근 본 자료
댓글(0)
0