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논문 기본 정보

자료유형
학술저널
저자정보
유주인 (제주대학교) 조영현 (제주대학교) 서태범 (제주대학교) 김영표 (제주대학교)
저널정보
한국운동재활학회 Journal of exercise rehabilitation Journal of exercise rehabilitation Vol.19 No.1
발행연도
2023.2
수록면
19 - 26 (8page)
DOI
10.12965/jer.2244006.003

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초록· 키워드

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The purpose of this study was to determine whether combined inter vention of treadmill exercise and bone marrow stromal cell (BMSC) transplantation would affect the expression of neurotrophic factors in the sciatic nerve injury (SNI) and neuropathic pain-related cascades in ipsilateral lumbar 4-5 dorsal root ganglion (DRG) during the early or late stage of sciatic nerve regeneration. The rats were randomly divided into the normal control group (CONT, n= 6), sedentary group (SS, n= 24), exercise group (SE, n= 24), BMSC transplantation group (SB, n= 24), BMSC transplantation+exercise group (SBE, n= 24) 1, 2, 3, and 5 weeks after SNI. Single dose of 5× 106 harvested BMSC was injected into the injury area sing by a 30 gauge needle. Treadmill exercise was performed at a speed of 8 m/min for 30 min once a day. Tropomyosin-receptor ki nase B, brain-derived neurotrophic factor and ciliary neurotrophic fac tor were significantly upregulated in the SE and SBE groups at 1- and 2-week postinjury than those in the CONT and SS groups, and SB and SBE groups continuously kept up proinflammatory cytokines until the late stage of regeneration. Nuclear factor kappa-light-chain-enhancer of activated B cells, interleukin and tumor necrosis factor alpha in ipsi lateral DRG were progressively decreased by exercise alone application and/or BMSC transplantation at early and late stage of regeneration. Present results provide reliable information that combined intervention of treadmill exercise and BMSC transplantation might be one of the ef fective treatment strategies for recovering sciatic nerve injury-induced neuropathic pain over time.

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