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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,721 - 1,726 (6page)
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Anaplastic thyroid carcinoma (ATC) is difficult to distinguish from other cancers, especially when its pathological features are atypical for ATC or when the tumor is totally undifferentiated and occurs after a considerable lapse of time, in an area remote from the original site of the tumor. Here, we present two patients (68-year-old man and 56-year-old woman) with rare manifestations of ATC, which were initially thought to be other malignancies. Immunohistochemical tests, using various markers, failed to provide information about the origin of these tumors. However, both patients had a history of papillary thyroid carcinoma (PTC) from several years ago and BRAF mutations were observed in the undifferentiated tumors, as well as in the previous PTCs. Therefore, we could make a diagnosis of ATC derived from PTC. As such, BRAF mutation analysis may serve as a useful tool for ATC diagnosis in challenging ATC cases.
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참고문헌 (13)
참고문헌 신청
Nagaiah G / 2011 / Anaplastic thyroid cancer: a review of epidemiology, pathogenesis, and treatment / J Oncol 2011:542358
Goutas N / 2008 / BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort / Anticancer Res 28:305~308
Kim SK / 2009 / Clinical and pathological features and the BRAF(V600E)mutation in patients with papillary thyroid carcinoma with and without concurrent Hashimoto thyroiditis / Thyroid 19:137~141
Nikiforova MN / 2003 / BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas / J Clin Endocrinol Metab 88:5399~5404
Carcangiu ML / 1985 / Anaplastic thyroid carcinoma. A study of 70 cases / Am J Clin Pathol 83:135~158
Goutas N / 2008 / BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort / Anticancer Res 28:305~308
Kim SK / 2009 / Clinical and pathological features and the BRAF(V600E)mutation in patients with papillary thyroid carcinoma with and without concurrent Hashimoto thyroiditis / Thyroid 19:137~141
Nikiforova MN / 2003 / BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas / J Clin Endocrinol Metab 88:5399~5404
Carcangiu ML / 1985 / Anaplastic thyroid carcinoma. A study of 70 cases / Am J Clin Pathol 83:135~158
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