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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,542 - 1,547 (6page)
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초록· 키워드
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Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms in the pharmacokinetics of oseltamivir and its active metabolite, oseltamivir carboxylate in humans. Nineteen healthy male subjects were enrolled, and their ABCB1 polymorphisms were evaluated. After the oral administration of 75 mg oseltamivir, the plasma concentrations of oseltamivir and oseltamivir carboxylate were measured. Pharmacokinetic analysis was carried out. Systemic exposure to oseltamivir and oseltamivir carboxylate was higher in the mutant group than in the wild-type and heterozygous groups. We suggest that ABCB1 polymorphisms affect the pharmacokinetics of oseltamivir in humans. Further studies in a large population are necessary to validate the results of this preliminary study (Clinical Trial Registration Information [CRIS] registry: http://cris.nih.go.kr, No. KCT0001903).
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ose A / 2008 / P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier / Drug Metab Dispos 36:427~434
Morimoto K / 2008 / Oseltamivir(Tamiflu)efflux transport at the blood-brain barrier via P-glycoprotein / Drug Metab Dispos 36:6~9
Davies BE. / 2010 / Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations / J Antimicrob Chemother 65(Suppl 2):ii5~ii10
He G / 1999 / Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802 / Clin Pharmacokinet 37:471~484
Hama R / 2007 / Oseltamivir’s adverse reactions : fifty sudden deaths may be related to central suppression / BMJ 335:59
Morimoto K / 2008 / Oseltamivir(Tamiflu)efflux transport at the blood-brain barrier via P-glycoprotein / Drug Metab Dispos 36:6~9
Davies BE. / 2010 / Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations / J Antimicrob Chemother 65(Suppl 2):ii5~ii10
He G / 1999 / Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802 / Clin Pharmacokinet 37:471~484
Hama R / 2007 / Oseltamivir’s adverse reactions : fifty sudden deaths may be related to central suppression / BMJ 335:59
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