지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 34 - 39 (6page)
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초록· 키워드
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Background: Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphisms and the analgesic effect of morphine for postoperative pain in children.Methods: A prospective study was conducted in 88 healthy children undergoing tonsillectomy, who received morphine during the operation. The postoperative pain score, frequency of rescue analgesics, and side effects of morphine were assessed in the post-anesthesia care unit. The children were genotyped for OPRM1 A118G, ABCB1 C3435T, and COMT Val158Met.Results: Children with at least one G allele for OPRM1 (AG/GG) had higher postoperative pain scores compared with those with the AA genotype at the time of discharge from the post-anesthesia care unit (P = 0.025). Other recovery profiles were not significantly different between the two groups. There was no significant relationship between genotypes and postoperative pain scores in analysis of ABCB1 and COMT polymorphisms. Conclusions: Genetic polymorphism at OPRM1 A118G, but not at ABCB1 C3435T and COMT Val158Met, influences the analgesic effect of morphine for immediate acute postoperative pain in children. (Korean J Pain 2016; 29: 34-39)
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Association of Paediatric Anaesthetists of Great Britain and Ireland / 2012 / Good practice in postoperative and procedural pain management, 2nd edition / Paediatr Anaesth 22(Suppl 1):1~79
Dahmani S / 2001 / Predictive factors of early morphine requirements in the post-anaesthesia care unit(PACU) / Br J Anaesth 87:385~389
Wu WD / 2009 / Polymorphism of the micro-opioid receptor gene(OPRM1 118A＞G)affects fentanyl-induced analgesia during anesthesia and recovery / Mol Diagn Ther 13:331~337
Oertel BG / 2006 / The mu-opioid receptor gene polymorphism 118A＞G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers / Pharmacogenet Genomics 16:625~636
Chou WY / 2006 / Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy / Anesthesiology 105:334~337
Dahmani S / 2001 / Predictive factors of early morphine requirements in the post-anaesthesia care unit(PACU) / Br J Anaesth 87:385~389
Wu WD / 2009 / Polymorphism of the micro-opioid receptor gene(OPRM1 118A＞G)affects fentanyl-induced analgesia during anesthesia and recovery / Mol Diagn Ther 13:331~337
Oertel BG / 2006 / The mu-opioid receptor gene polymorphism 118A＞G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers / Pharmacogenet Genomics 16:625~636
Chou WY / 2006 / Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy / Anesthesiology 105:334~337
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