지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 509 - 517 (9page)
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초록· 키워드
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Purpose Dose-limiting toxicities of docetaxel are widely considered to be neutropenia, anemia, skin toxicity, and nausea. One of the factors that limit the use of docetaxel is its unpredictability of inter-individual variation in toxicity.
Materials and Methods In order to identify the genetic factors that affect the risk of docetaxel-induced toxicities, we recruited patients who received docetaxel chemotherapy. We genotyped 92 patients with single-nucleotide polymorphisms (SNPs) in 5 genes: CYP3A4 (CYP3A4*1B, CYP3A4*18, and CYP3A4*3), CYP3A5 (CYP3A5*2 and CYP3A5*3), ABCB1 (C1236T, G2677G/T, and C3435T), SLCO1B3 (rs11045585), and ABCC2 (rs12762549).
Results Out of 92 patients, 70 had grade 3 or 4 neutropenia; 4 had grade 1 or 2; and 18 had no toxicity (76.1%, 4.3%, and 19.6%, respectively). The findings of the SNP analysis showed that patients with TT genotype of ABCB1 3435C>T polymorphism showed significantly higher risk of neutropenia and anemia (p=0.029 and p=0.044, respectively). There were significant associations between docetaxel-induced leucopenia and 2677G/T of ABCB1 and rs12762549 of ABCC2 (p=0.025 and p=0.028, respectively). In a multivariate analysis, we observed that patients carrying 2677G>T in ABCB1might be associated with higher risk of chemo-resistance when treated with docetaxel (odds ratio [OR], 6.48; confidence interval, 1.92 to 21.94; p=0.003). In a subgroup analysis of non-small cell lung cancer patients, a significant association of tumor response with G2677T/A (OR, 4.54) in ABCB1 and SLCO1B3 (OR, 9.44) was observed.
Conclusion Our data suggest that ABCB1 (2677G/T) and SLCO1B3 (rs11055585) might be major genetic predictors of docetaxel-related toxicities in patients receiving docetaxel chemotherapy.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Maemondo M / 2014 / Randomized phase II trial comparing carboplatin plus weekly paclitaxel and docetaxel alone in elderly patients with advanced non-small cell lung cancer : north japan lung cancer group trial 0801 / Oncologist 19:352~353
Quoix E / 2011 / Chemotherapy in elderly patients with advanced non-small cell lung cancer / Lung Cancer 74:364~368
Awada Z / 2013 / Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients : paving the w
Baker SD / 2009 / Pharmacogenetic pathway analysis of docetaxel elimination / Clin Pharmacol Ther 85 : 155 ~ 163
Bosch TM / 2006 / Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel / Clin Cancer Res 12 : 5786 ~ 5793
Quoix E / 2011 / Chemotherapy in elderly patients with advanced non-small cell lung cancer / Lung Cancer 74:364~368
Awada Z / 2013 / Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients : paving the w
Baker SD / 2009 / Pharmacogenetic pathway analysis of docetaxel elimination / Clin Pharmacol Ther 85 : 155 ~ 163
Bosch TM / 2006 / Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel / Clin Cancer Res 12 : 5786 ~ 5793
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