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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,016 - 1,023 (8page)
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초록· 키워드
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A multi-center, randomized, double-blind, placebo-controlled study was conducted with 158 subjects who were randomized to placebo or avanafil 50, 100, and 200 mg on demand for 8 weeks to evaluate the safety, tolerability, and efficacy of avanafil in the treatment of erectile dysfunction (ED) in Korean men. The primary outcome was the erectile function (EF) domain score of the International Index of Erectile Function (IIEF) questionnaire. Secondary outcomes included changes in the scores of IIEF questions 3 and 4 (IIEF Q3, Q4) from baseline, changes in all domain scores in the IIEF from baseline, Sexual Encounter Profile questions 2–5 (SEP2–5), the Global Efficacy Assessment Question (GEAQ), and the number of subjects whose EF domain score at the 8th week visit was ≥ 26. After 8 weeks of treatment, the dose groups except avanafil 50 mg scored significantly higher on the IIEF-EF domain from baseline than the placebo group. The changes from baseline in the avanafil group in IIEF Q3 (all doses) and Q4 (200 mg alone) were higher than the placebo group. The differences between avanafil and placebo groups were significant in SEP2 (100 and 200 mg) and SEP3–5 (200 mg). The differences in the GEAQ “Yes” response were also significant in the avanafil 100 and 200 mg groups. Regarding the ratio of normal EF at the end of the study, avanafil 200 mg differed significantly from the placebo. Most treatment-associated adverse events were mild and resolved spontaneously. This is a clinical trial study and was registered at www.ClinicalTrials.gov (Identifier: NCT02477436).
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Goldstein I / 1998 / Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group / N Engl J Med 338:1397~1404
박정현 / 2015 / Body mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health / Investigative and Clinical Urology 56(5):386~392
Lutfi Canat / 2015 / Association between renal function, erectile function and coronary artery disease: Detection with coronary angiography / Investigative and Clinical Urology 56(1):76~81
고경태 / 2014 / Effect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and Solifenacin / Investigative and Clinical Urology 55(9):608~614
Kenneth J DeLay / 2016 / Modifying Risk Factors in the Management of Erectile Dysfunction: A Review / The World Journal of Men's Health 34(2):89~100
박정현 / 2015 / Body mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health / Investigative and Clinical Urology 56(5):386~392
Lutfi Canat / 2015 / Association between renal function, erectile function and coronary artery disease: Detection with coronary angiography / Investigative and Clinical Urology 56(1):76~81
고경태 / 2014 / Effect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and Solifenacin / Investigative and Clinical Urology 55(9):608~614
Kenneth J DeLay / 2016 / Modifying Risk Factors in the Management of Erectile Dysfunction: A Review / The World Journal of Men's Health 34(2):89~100
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