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Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea
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논문 기본 정보

Type
Academic journal
Author
Sol-Jae Lee (부천 세종병원 내과) 정수진 (세종병원) Yu-Chang Lee (부천 세종병원 내과) Yong-Hoon Lee (부천 세종병원 내과) Jung-Eun Lee (부천 세종병원 내과) 김종화 (부천세종병원) KyungWan Min (을지대학교) Cha Bong Yun (가톨릭대학교)
Journal
대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.41 No.4 KCI Accredited Journals
Published
2017.1
Pages
275 - 283 (9page)

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Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea
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Background: Diabetic cardiac autonomic neuropathy (CAN) is one of the important complications of diabetes. It is characterized by reduced heart rate variability (HRV). Methods: In this randomized, double-blind, placebo-controlled, multicenter trial, 75 patients were randomly assigned to one of two groups. One group (n=41) received α-lipoic acid (ALA) at an oral dose of 600 mg/day for the first 12 weeks and then 1,200 mg/day for the next 12 weeks. The other group (n=34) received placebo treatment for 24 weeks. CAN was assessed by measuring HRVs in people with diabetes. Results: Most of the baseline measures for HRVs were similar between the ALA and placebo groups. Although there were no statistically significant HRV changes in the ALA group compared to the placebo group after 24 weeks of trial, we found a positive tendency in some of the HRV parameters of the ALA group. The standard deviations of normal-to-normal RR intervals in the standing position increased by 1.87 ms in the ALA group but decreased by –3.97 ms in the placebo group (P=0.06). The power spectrum of the low frequency (LF) band in the standing position increased by 15.77 ms2 in the ALA group, whereas it declined by –15.04 ms2 in the placebo group (P=0.08). The high frequency/LF ratio in the upright position increased by 0.35 in the ALA group, whereas it declined by –0.42 in the placebo group (P=0.06). There were no differences between the two groups regarding rates of adverse events. Conclusion: Although a slight improvement tendency was seen in HRV in the ALA group, there were no statistically significant HRV changes in the ALA group compared to the placebo group after 24 weeks of trial. However, the high oral dose of ALA was well-tolerated.

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References (24)

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Pop-Busui R / 2010 / Cardiac autonomic neuropathy in diabetes: a clinical perspective / Diabetes Care 33:434~441 google schola Orchard TJ / 1996 / Why does diabetic autonomic neuropathy predict IDDM mortality? An analysis from the Pittsburgh Epidemiology of Diabetes Complications Study / Diabetes Res Clin Pract 34(Suppl):S165~171 google schola Lee KH / 2003 / Prognostic value of cardiac autonomic neuropathy independent and incremental to perfusion defects in patients with diabetes and suspected coronary artery disease / Am J Cardiol 92:1458~1461 google schola Astrup AS / 2006 / Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy / Diabetes Care 29:334~339 google schola Gerritsen J / 2001 / Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study / Diabetes Care 24:1793~1798 google schola

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