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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 117 - 125 (9page)
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초록· 키워드
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Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is an emerging problem in Asia, but little is known about the disease in the nonobese population. The aims of this study were to investigate the prevalence of NAFLD and the factors associated with it in a nonobese Korean population and to compare the clinical characteristics of nonobese and obese subjects with NAFLD. Methods: This cross-sectional study used data from 2,058 subjects who participated in a medical checkup program. Results: The prevalence of NAFLD was 12.4% (213/1,711) in the nonobese population. A higher body mass index (BMI), higher homeostasis model assessment of insulin resistance (HOMA-IR) values, higher alanine aminotransferase (ALT) levels, triglyceride concentrations ≥150 mg/dL, and hyperuricemia were independently associated with the presence of NAFLD in the nonobese subjects. Compared with the obese subjects with NAFLD, the nonobese subjects with NAFLD were composed of a higher proportion of females and had lower BMIs, smaller waist circumferences, lower HOMA-IR values, and fewer metabolic irregularities. Conclusions: Higher BMIs, HOMA-IR values, ALT levels, hypertriglyceridemia, and hyperuricemia were associated with NAFLD in the nonobese subjects. Clinicians should be particularly aware of the possibility of NAFLD in nonobese Asian people.
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참고문헌 (47)
참고문헌 신청
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Kojima S / 2003 / Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background / J Gastroenterol 38:954~961
Neuschwander-Tetri BA / 2003 / Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference / Hepatology 37:1202~1219
Farrell GC / 2007 / Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary / J Gastroenterol Hepatol 22:775~777
Das K / 2010 / Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease / Hepatology 51:1593~1602
Kojima S / 2003 / Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background / J Gastroenterol 38:954~961
Neuschwander-Tetri BA / 2003 / Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference / Hepatology 37:1202~1219
Farrell GC / 2007 / Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary / J Gastroenterol Hepatol 22:775~777
Das K / 2010 / Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease / Hepatology 51:1593~1602
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