지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,128 - 1,134 (7page)
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초록· 키워드
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Purpose: International consensus criteria for antiphospholipid syndrome (APS) require persistently positive antiphospholipid antibodies (aPL) and medium or high titers in association with clinical manifestations. However, the clinical relevance of persistenceand titers of aPL in patients with stroke has not been identified. We aimed to investigate the risk of subsequent thrombotic events in patients with ischemic stroke with aPL positivity in terms of aPL status.
Materials and Methods: We reviewed the medical records of 99 patients with ischemic stroke with at least one or more aPL-positivity (i.e., positivity for aCL, anti-β2-glycoprotein-1, and/or lupus anticoagulants). The patients were divided into two groups: “definite APS” who fulfilled the laboratory criteria and “indefinite APS” who fell short of the criteria. We compared the risk of subsequent thromboticevents between the two groups. Cox proportional hazards model and Kaplan-Meier survival curves were used for the analyses.
Results: Of the 99 patients, 46 (46%) were classified as having definite APS and 53 (54%) as having indefinite APS. The mean follow-up was 51.6 months. Overall event numbers were 14 (30.4%) in definite APS and 16 (30.2%) in indefinite APS. Increased subsequentthrombotic events (hazard ratio 1.039; 95% confidence interval 0.449−2.404; p=0.930) and decreased time to thrombotic events (log-rank p=0.321) were not associated with aPL status.
Conclusion: There was no increased risk of subsequent thrombotic events in ischemic stroke patients with definite APS, compared with those with indefinite APS.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Amory CF / 2015 / Antiphospholipid antibodies and recurrent thrombotic events: persistence and portfolio / Cerebrovasc Dis 40 : 293 ~ 300
Brey RL / 2001 / β2-Glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: the honolulu heart program / Stroke 32 : 1701
Erkan D / 2010 / Moderate versus high-titer persistently anticardiolipin antibody positive patients: are they clinically different and does high-titer anti-β2-glycoprotein-I
Espinosa G / 2015 / Current treatment of antiphospholipid syndrome:lights and shadows / Nat Rev Rheumatol 11 : 586 ~ 596
Forastiero R / 2005 / A prospective study of antibodies to β2-glycoprotein I and prothrombin, and risk of thrombosis / J Thromb Haemost 3 : 1231 ~ 1238
Brey RL / 2001 / β2-Glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: the honolulu heart program / Stroke 32 : 1701
Erkan D / 2010 / Moderate versus high-titer persistently anticardiolipin antibody positive patients: are they clinically different and does high-titer anti-β2-glycoprotein-I
Espinosa G / 2015 / Current treatment of antiphospholipid syndrome:lights and shadows / Nat Rev Rheumatol 11 : 586 ~ 596
Forastiero R / 2005 / A prospective study of antibodies to β2-glycoprotein I and prothrombin, and risk of thrombosis / J Thromb Haemost 3 : 1231 ~ 1238
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